In patients with this disorder, the steroid precursors are converted to progesterone and then to products with mineralocorticoid activity such as 11-deoxycorticosterone
We measured 15 adrenal steroids simultaneously by LCMS/MS, including aldosterone, cortisol, 18-oxocortisol, 18-hydroxycortisol, cortisone, 11-deoxycortisol, 21deoxycortisol, corticosterone, 11-deoxycorticosterone
, progesterone, 17-hydroxyprogesterone, pregnenolone, androstenedione, dehydroepiandrosterone (DHEA), and DHEA-sulfate (DHEA-S).
71) However, both forms of CYP11B1 were capable of catalyzing aldosterone formation as well as the 11[beta]-and 18-hydroxylation of 11-deoxycorticosterone
, although the intensities of those enzymatic activities of the two forms were slightly different.
11-beta hydroxylase mediates the final step in the glucocorticoid pathway and the conversion of 11-deoxycorticosterone
(DOC) into corticosterone.
All core clinical biochemistry and hormonal tests were performed at Royal Hospital, Oman, using Architect 8000c and Architect 2000i, respectively, with Automated Processing System (Abbott, USA); and 17[alpha]-hydroxyprogesterone, renin and aldosterone were performed by ELISA (DRG, USA); while 11-deoxycortisol, 11-deoxycorticosterone
, corticosterone, androstenedione and ACTH were performed at Laboratoroire Cerba (France).
21 (alpha) OHD deficiency leading to failure of conversion of progesterone to 11-deoxycorticosterone
may result in aldosterone deficiency which is called "salt losing type" of CAH.
(DOC) and mineralocorticoid receptor testicular expression during rainbow trout, Oncorhynchus mykiss, spermiation: implication with 17 alpha, 20 betadihydroxyprogesterone on the milt fluidity?