LPV/r-containing regimens); and (iv) comparing EFV-based regimens (D4T + 3TC
+ EFV v.
sup],, Both viral infections can be treated with the nucleoside reverse transcriptase inhibitors (NRTIs) such as tenofovir disoproxil fumarate (TDF) and lamivudine (3TC
), and it is recommended that antiretroviral therapy (ART) for HIV/HBV co-infection should be initiated with the combination of TDF + 3TC
or TDF + emtricitabine (FTC) as the NRTI backbone of a regimen.
For patients who were receiving d4T, 3TC
and EFV prior to the switch, clinicians should please ensure that they have a recent undetectable viral load (VL) (~1 000 copies/ml) and normal creatinine clearance within the previous 3-6 months.
As noted in this study, the schemes composed of EFZ + ATC and EFZ + 3TC
+ TDF showed high rates of compliance, low cost and low percentage of treatments change, when compared to regimens consisting of ATC + NVP, DDI400 + 3TC
+ EFZ, ATC + LPV / R, ATV300 + ATC + RTV and TDF + 3TC
+ RTV + ATV300 for use in initial therapy.
In one patient (ID 14) who had previously been exposed to several therapeutic regimens containing ZDV, 3TC
, NFV and RTV, the viral load first reached undetectable levels in October 2001 while the patient was undergoing the eighth therapeutic regimen, which contained d4T, ddI, EFV and LPV/r.
Drugs: Twenty tablets/capsules of NVP (Nevirex 200, Aurobindo Pharma Limited, India), 3TC
(Lamivox 150, Aurobindo Pharma Limited, India), d4T (Stavir 30, Cipla, India) each were analysed for their drug content by HPLC and spectrophotometric methods.
TDF with EFV and either 3TC
or FTC have been shown to have high and durable virological activity with good tolerability and minimal long-term toxicity with up to 3 years of follow-up [25,31].
4 log drop in viral load in the subset of patients who were not receiving 3TC
or FTC in their background treatment regimen versus a 0.
Q: After several years of taking the protease inhibitor nelfinavir (Viracept) with the combination of AZT and 3TC
(Combivir) as my first regimen, my viral load has started to climb above 2000.
Patients generally take a combination of AZT, 3TC
, and one of the protease inhibitors such as ritonavir, indinavir, or saquinavir, says Zhang.
Fewer patients in the arm containing Sustiva, AZT and 3TC
(6 percent) dropped out due to adverse events than in the Crixivan/AZT/3TC
arm (19 percent).
All of them work best in combination with other drugs, including AZT (zidovudine), ddC (HIVID), and 3TC
(Epivir), which cripple a different viral enzyme.