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3TC

   Also found in: Acronyms, Wikipedia 0.01 sec.
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Noun1.3TC - a nucleoside reverse transcriptase inhibitor that is very effective in combination with zidovudine in treating AIDS and HIV
lamivudine
NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
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4 log drop in viral load in the subset of patients who were not receiving 3TC or FTC in their background treatment regimen versus a 0.
PHASE IIB STUDY SHOWS REVERSET ACHIEVES ANTIVIRIRAL BENEFIT by Worldwide Biotech
Because of its low toxicity, good pharmacokinetics (eventually being approved for once-daily use) and the Pact that 3TC-resistant HIV was less fit and mutated more slowly than wild-type HIV, 3TC eventually became the most commonly used drug in HIV combination therapy.
Ten years of HAART by Harrington, Mark / Research Initiative/Treatment Action!
Until the studies began, the combination of AZT and 3TC offered the best chance of extending life, but these two drugs offered little chance of reducing the virus to undetectable levels.
AIDS THERAPY HOLDS PROMISE : VIRUS SUPPRESSED IN STUDIES by Daily News (Los Angeles, CA)
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