Throughout Chris Meletis's clinical career working from the foundational base of the neuroendocrine theory of aging, he has postulated a concept that he terms the NeSID (neuroendocrine stress-induced dysfunction) effect, which incorporates the role of stress on both the 5-alpha reductase
and COMT pathways.
Small Molecules to Inhibit Steroidal 5-Alpha Reductase
for Benign Prostatic Hyperplasia
Gann suggested starting with compounds--especially dietary agents--that could inhibit 5-alpha reductase
20) The current approach for medical management of LUTS associated with BPH depends on the usage of alpha-1 receptor blockers, such as alfuzosin, doxazosin, silodosin, tamsulosin and terazosin or suppression of the hormonal growth of the prostate by the 5-alpha reductase
inhibitors finasteride and dutasteride.
127) 5-alpha reductase
is the enzyme that converts testosterone to DHT.
A novel missense mutation of 5-alpha reductase
type 2 gene (SRD5A2) leads to severe male pseudohermaphroditism in a Turkish family.
The two main classes of BPH drugs: alpha blockers like Flomax and UroXatral, which relax the muscles of the bladder neck and prostate, and 5-alpha reductase
inhibitors like Proscar and Avodart, which lower levels of hormones produced by the prostate.
Finasteride, a type II 5-alpha reductase
inhibitor that blocks the conversion of testosterone to dihydrotestosterone, is used for the treatment of androgenic alopecia and has also been shown to decrease the incidence of prostate cancer.
Laboratory research has shown that mushroom extract can lower levels of 5-alpha reductase
, an enzyme linked to male hormones involved in prostate cancer.
The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase
, and citrate lyase.
Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-alpha reductase
3-7) Its mechanism of action is believed to be derived from the stimulation of estrogenic and inhibition of progesterone receptors in prostatic tissues, (8) but it also exhibits antiestrogenic and antiandrogenic effects, inhibiting the actions of 5-alpha reductase
enzyme and also the binding of dihydrotestosterone to androgen receptors.