The PCPT was a Phase III, randomized, double-blind, placebo-controlled clinical trial of finasteride, a 5a-reductase
inhibitor, for the prevention of prostate cancer.
Molecular epidemiologic studies have identified several specific genetic polymorphisms, including in the 5a-reductase
type 2 gene, androgen-responsive genes, and related microRNAs.
Spironolactone is an androgen receptor and 5a-reductase
blocker, and its antiandrogen effects can improve acne.
The patent offers once-weekly oral administration of selective inhibitors of type 1 and/or type 2 isoforms of steroid 5a-reductase
, to patients with nodulocystic and conglobate acne vulgaris.
These four pomegranate compounds inhibited DHT-stimulated androgen receptor nuclear accumulation and the expression of the androgen receptor-dependent genes prostate specific antigen and steroid 5a-reductase
type 1 at concentrations =10 [micro]M.
The Risks and Benefits of 5a-Reductase
Inhibitors for Prostate-Cancer Prevention.
They compared 2312 Icelandic men who underwent medical or surgical management for BPH (including treatment with 5a-reductase
inhibitors, which are known to lower the PSA concentration) vs 33 779 presumed-healthy Icelandic men.
Washington, March 08 (ANI): A new study has shown that 5a-reductase
inhibitors, commonly used to treat urinary problems in patients with benign prostatic hyperplasia (BPH) and found in popular medications to treat hair loss, can produce, persistent erectile dysfunction (ED), depression and loss of libido, even after the medication has been discontinued.
The oligomeric stilbenes have been shown have many interesting biological activities such as: as inhibitor of 5a-reductase
(Hirano et al.
A second category of medicines includes what are termed the 5a-reductase
inhibitors, including Proscar and Avodart.
Finasteride, an inhibitor of 5a-reductase
, inhibits the conversion of testosterone to dihydrotestosterone, the primary androgen in the prostate, and may reduce the risk of prostate cancer.
46) Repeating for emphasis: As more insulin is applied, more 5a-reductase