mercaptopurine

(redirected from 6-MP)
Also found in: Thesaurus, Medical, Acronyms, Encyclopedia.

mer·cap·to·pu·rine

 (mər-kăp′tō-pyo͝or′ēn)
n.
A purine analog, C5H4N4S, that interferes with the synthesis of purines and is used primarily in the treatment of certain forms of leukemia.

mercaptopurine

(məˌkæptəʊˈpjʊəriːn)
n
(Pharmacology) a drug used in the treatment of leukaemia. Formula: C5H4N4S
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mercaptopurine - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
References in periodicals archive ?
The thiopurines AZA and 6-MP are cytotoxic and immunosuppressive drugs that constitute the cornerstone ofmaintenance therapyfor inflammatorybowel disease (IBD).
Three cases of 6-MP hepatotoxicity were identified from the teaching case files of one of the authors, dating from 2007 to 2011.
Contributing to this anxiety are warnings in the drug's label that it "can cause fetal harm" when used in pregnancy, and the fact that azathioprine and 6-MP are purine antimetabolites.
Conclusions: Higher TPMT activity is associated with lower 6-TGN levels and higher 6-MMPN levels in patients with IBD who were treated with AZA or 6-MP in clinical practice.
Prior to the signing of the settlement agreement, Prometheus had filed a patent infringement lawsuit against Specialty alleging that the use or sale of Specialty's 6-MP Drug MonitR assay infringed certain of Prometheus' patent rights.
Patients with a history of cancer of any type, definite dysplasia of the colon within the last 5 years, or clinically significant renal or hepatic disease were ineligible, as were pregnant or breast-feeding women, patients who were allergic to AZA or 6-MP, and patients receiving allopurinol.
An analysis predicted that 43% of all patients would survive without colectomies, but that significantly more patients who also received 6-MP or azathioprine would survive without colectomy after 12 years than those who received cyclosporine alone (54% vs.
Probably safe drugs: 6-MP, azathioprine, ciprofloxacin, metronidazole, and cyclosporine.
In one patient series, IBD patients with impaired TPMT activity accounted for half of all cases of leukopenia and 27% of all cases of severe myelosuppression during 87 months of 6-MP or azathioprine therapy
Thiopurine methyltransferase (TPMT) inactivates 6-MP by methylation.