mercaptopurine

(redirected from 6-mercaptopurine)
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mer·cap·to·pu·rine

 (mər-kăp′tō-pyo͝or′ēn)
n.
A purine analog, C5H4N4S, that interferes with the synthesis of purines and is used primarily in the treatment of certain forms of leukemia.

mercaptopurine

(məˌkæptəʊˈpjʊəriːn)
n
(Pharmacology) a drug used in the treatment of leukaemia. Formula: C5H4N4S
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mercaptopurine - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
References in periodicals archive ?
Researchers Identify Children Most at Risk of Over-Reporting Adherence to At-Home Chemotherapy Regimen 6-Mercaptopurine (6MP) Intake during Maintenance for Childhood Acute Lymphoblastic Leukemia (ALL) - a Comparison of Self-Report and Electronic Monitoring: A Report from the Children's Oncology Group (COG) Study AALL03N1 [559]
Contract awarded for 6-mercaptopurine, cisplatin, hydroxyurea, acetic acid, succinylcholine and lidocaine 10% spray liquid
is also the first and only subcutaneous anti-tumor necrosis factor (TNF)-alpha treatment administered as an every-four-week maintenance therapy for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response to conventional therapy, including corticosteroids and 6-mercaptopurine or azathioprine, or who are intolerant to or have medical contraindications for such therapies.
Grotegut and his associates at Duke most commonly use azathioprine and 6-mercaptopurine.
Children were defined as having IBD if they had either three or more health care visits for Crohn's disease or ulcerative colitis during the study's time frame, or "at least one health care contact for Crohn's disease or ulcerative colitis and at least one pharmacy claim for any of the following medications: mesalamine, olsalazine, balsalazide, sulfasalazine, 6-mercaptopurine, azathioprine, methotrexate, enteral budesonide, or biologies (infliximab, adalimumab, certolizumab, or natalizumab).
azathioprine, 6-mercaptopurine and antitumour necrosis factor.
In rheumatoid arthritis, methotrexate was the most effective companion agent, while in Crohn's disease, azathioprine and 6-mercaptopurine seemed to be effective in preventing AABs.
The patient was switched to another thiopurine drug, 6-mercaptopurine (6-MP), at 75 mg/day (1.
Toxicity of low dose azathioprine and 6-mercaptopurine in rat hepatocytes.
Hepatotoxicity can occur with either of the two thiopurine analogs in use for IBD treatment, azathioprine (AZA) and 6-mercaptopurine (6-MP), and varies in severity, timing, and clinical presentation.
The study also was unique in that patients were permitted to continue taking concomitant medications such as azathioprine, 6-mercaptopurine, methotrexate, aminosalicylates, antibiotics, prednisone, or budesonide.