mercaptopurine

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mer·cap·to·pu·rine

 (mər-kăp′tō-pyo͝or′ēn)
n.
A purine analog, C5H4N4S, that interferes with the synthesis of purines and is used primarily in the treatment of certain forms of leukemia.

mercaptopurine

(məˌkæptəʊˈpjʊəriːn)
n
(Pharmacology) a drug used in the treatment of leukaemia. Formula: C5H4N4S
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mercaptopurine - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
References in periodicals archive ?
Immunomodulators, such as azathioprine (Imuran, Azasan) or 6-mercaptopurine (Purinethol, Purixan)
Azathioprine and 6-mercaptopurine can also cause side effects, including allergic reactions, leucopenia, pancreatitis, nausea, and abnormal liver function tests.
Hepatosplenic T-cell lymphoma, a rare form of fatal lymphoma, has occurred mostly in teenage or young adult males with Crohns disease or ulcerative colitis who were taking infliximab products and azathioprine or 6-mercaptopurine.
Food and Drug Administration (FDA) has been aggressive in providing genetic labeling on new drugs, and also updating product labels for a number of existing therapies, such as warfarin and 6-mercaptopurine.
Fraser et al, 2002 Adverse effects of Ulcerative colitis azathioprine in the 6-mercaptopurine treatment of inflammatory bowel disease Martinez et al, 2001 Adverse events of 6-mercaptopurine thiopurine Smoking immunomodulators in patients with inflammatory bowel disease.
Medical therapy includes mesalamine, steroids, 5-aminosalicylate, 6-mercaptopurine, azathioprine, infliximab, and thiopurines.
Patients taking 6-mercaptopurine with xanthine oxidase inhibitors may experience cellular toxicity, as these drugs inhibit the metabolism of 6-mercaptopurine by the enzyme thiopurine methyltransferase, raising its plasma concentration.
Predisposing Drugs Antituberculosis agents: Isoniazid Pyrazinamide Antiepileptic drugs: Hydantoins Ethionamide Phenobarbital Diazepam Chemotherapy and immunosuppressive drugs 6-Mercaptopurine 5-Fluorouracil Chlorambucil Azathioprine Chloramphenicol
It has been most commonly reported after intravenous use of chemotherapeutic agents such as 5-fluorouracil, docetaxel and combinations of methotrexate, cytosine arabinoside, daunorubicin, 6-mercaptopurine, cyclophosphamide, doxorubicin, bleomycin, vinka alkaloids and dacarbazine.