Isab, 13C NMR studies the interaction of gold (I) thiomalate with 6-mercaptopurine
and its derivatives, J.
Immunomodulators, such as azathioprine (Imuran, Azasan) or 6-mercaptopurine
Azathioprine and 6-mercaptopurine
can also cause side effects, including allergic reactions, leucopenia, pancreatitis, nausea, and abnormal liver function tests.
Hepatosplenic T-cell lymphoma, a rare form of fatal lymphoma, has occurred mostly in teenage or young adult males with Crohns disease or ulcerative colitis who were taking infliximab products and azathioprine or 6-mercaptopurine
Food and Drug Administration (FDA) has been aggressive in providing genetic labeling on new drugs, and also updating product labels for a number of existing therapies, such as warfarin and 6-mercaptopurine
Fraser et al, 2002 Adverse effects of Ulcerative colitis azathioprine in the 6-mercaptopurine
treatment of inflammatory bowel disease Martinez et al, 2001 Adverse events of 6-mercaptopurine
thiopurine Smoking immunomodulators in patients with inflammatory bowel disease.
Medical therapy includes mesalamine, steroids, 5-aminosalicylate, 6-mercaptopurine
, azathioprine, infliximab, and thiopurines.
Patients taking 6-mercaptopurine
with xanthine oxidase inhibitors may experience cellular toxicity, as these drugs inhibit the metabolism of 6-mercaptopurine
by the enzyme thiopurine methyltransferase, raising its plasma concentration.
d [sup]-1 , days 1-3 and 8-10; 6-mercaptopurine
Predisposing Drugs Antituberculosis agents: Isoniazid Pyrazinamide Antiepileptic drugs: Hydantoins Ethionamide Phenobarbital Diazepam Chemotherapy and immunosuppressive drugs 6-Mercaptopurine
5-Fluorouracil Chlorambucil Azathioprine Chloramphenicol
It has been most commonly reported after intravenous use of chemotherapeutic agents such as 5-fluorouracil, docetaxel and combinations of methotrexate, cytosine arabinoside, daunorubicin, 6-mercaptopurine
, cyclophosphamide, doxorubicin, bleomycin, vinka alkaloids and dacarbazine.
He remained symptomatic, and oral 6-mercaptopurine
, 50 mg once a day, was prescribed.