Researchers Identify Children Most at Risk of Over-Reporting Adherence to At-Home Chemotherapy Regimen 6-Mercaptopurine
(6MP) Intake during Maintenance for Childhood Acute Lymphoblastic Leukemia (ALL) - a Comparison of Self-Report and Electronic Monitoring: A Report from the Children's Oncology Group (COG) Study AALL03N1 
Contract awarded for 6-mercaptopurine
, cisplatin, hydroxyurea, acetic acid, succinylcholine and lidocaine 10% spray liquid
is also the first and only subcutaneous anti-tumor necrosis factor (TNF)-alpha treatment administered as an every-four-week maintenance therapy for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response to conventional therapy, including corticosteroids and 6-mercaptopurine
or azathioprine, or who are intolerant to or have medical contraindications for such therapies.
He remained symptomatic, and oral 6-mercaptopurine
, 50 mg once a day, was prescribed.
Grotegut and his associates at Duke most commonly use azathioprine and 6-mercaptopurine
Children were defined as having IBD if they had either three or more health care visits for Crohn's disease or ulcerative colitis during the study's time frame, or "at least one health care contact for Crohn's disease or ulcerative colitis and at least one pharmacy claim for any of the following medications: mesalamine, olsalazine, balsalazide, sulfasalazine, 6-mercaptopurine
, azathioprine, methotrexate, enteral budesonide, or biologies (infliximab, adalimumab, certolizumab, or natalizumab).
and antitumour necrosis factor.
In rheumatoid arthritis, methotrexate was the most effective companion agent, while in Crohn's disease, azathioprine and 6-mercaptopurine
seemed to be effective in preventing AABs.
The patient was switched to another thiopurine drug, 6-mercaptopurine
(6-MP), at 75 mg/day (1.
Toxicity of low dose azathioprine and 6-mercaptopurine
in rat hepatocytes.
Hepatotoxicity can occur with either of the two thiopurine analogs in use for IBD treatment, azathioprine (AZA) and 6-mercaptopurine
(6-MP), and varies in severity, timing, and clinical presentation.
The study also was unique in that patients were permitted to continue taking concomitant medications such as azathioprine, 6-mercaptopurine
, methotrexate, aminosalicylates, antibiotics, prednisone, or budesonide.