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Related to ADIPOQ: Adiponectin, Resistin


A polypeptide hormone that is secreted by fat cells and regulates glucose and lipid metabolism, especially by increasing insulin sensitivity and muscle uptake of glucose and by decreasing glucose production in the liver.

[Latin adeps, adip-, fat + Latin nectere, to bind; see ned- in Indo-European roots + -in.]
References in periodicals archive ?
Methods: Most deleterious nonsynonymous single nucleotide polymorphisms in the coding region of the ADIPOQ gene were investigated using SNP databases, and detected nonsynonymous variants were analyzed in silico from the standpoint of relevant protein function and stability by using SIFT, PolyPhen-2, PROVEAN and MUpro, I-Mutant2.
Result: A total of 58 nonsynonymous SNPs consisting of 55 missense variations, 3 non-sense variations were found in the ADIPOQ gene.
ADIPOQ and LEPR mRNA levels were not affected by CE treatments (10 and 100 [micro]g/ml, 2 h) (data not shown).
Association of C45G15G(T/G) and C276(G/T) polymorphisms in the ADIPOQ gene with polycystic ovary syndrome among Han Chinese women.
La adiponectina participa en la diferenciacion del adipocito, que ejerce efectos metabolicos favorables tales como aumentar la sensibilidad a la insulina, inhibir la inflamacion y la aterogenesis, es codificada por el gen ADIPOQ, y sus polimorfismos han sido asociados con Diabetes Mellitus tipo 2 (DM2), obesidad y Sindrome Metabolico (SM).
Impact of KCNJ11 TCF7L2 SLC30A8 IGF2BP2 PPARG SLC47A1 STK11 HHEX KCNQ1 CDKAL1 FTO CYP2C9 ADIPOQ CAPN10 gene polymorphisms on risk of type 2 diabetes and therapeutic response to sulfonylurea and metformin therapy.
ADIPOQ gene variations have also been shown to be associated with adiponectin plasma concentrations (11-18).
Third, based on the strong functional link between CDH13 and adiponectin, we looked up the GWIS result of SNPs in the ADIPOQ gene, the adiponectin precursor protein, for interaction with [PM.
The following genes were examined: ADIPOQ (adiponectin), FABP4 (fatty acid binding protein 4), FSP27 (fatspecific protein of 27 kDa), LEP (leptin), and LPL (lipoprotein lipase).