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AIDS dementia complex

   Also found in: Medical, Legal, Acronyms, Encyclopedia, Wikipedia, Hutchinson 0.02 sec.
AIDS dementia complex
n.
The neurological disease complex that is sometimes experienced by AIDS patients, caused by neuron injury and death and characterized by cognitive impairment.


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AIDS dementia complex (ADC) is one of the most common CNS complications among individuals with a diagnosis of AIDS (Price, 1995).
In addition, macrophages are the main infected cells in organs such as the brain and lungs, and appear to be responsible for inflammation and injury in these sites, which lead to neurological dysfunction and AIDS Dementia Complex (ADC), or pulmonary inflammation and Lymphoid Interstitial Pneumonitis (LIP).
Lipton, Director of the Laboratory of Cellular and Molecular Neuroscience at Children's Hospital, said, "Excessive activation of the glutamate type of NMDA receptors appears to play a role in neuronal injury and death in a variety of pathologic conditions including chronic neurodegenerative disorders such as AIDS dementia complex.
 
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