ascus

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Related to ASC-US: colposcopy, ASC-H

as·cus

 (ăs′kəs)
n. pl. as·ci (ăs′ī′, -kī′)
A membranous, often club-shaped structure in ascomycetes in which karyogamy occurs, followed by the formation of eight haploid ascospores.

[New Latin, from Greek askos, bag.]

ascus

(ˈæskəs)
n, pl asci (ˈæsaɪ; ˈæskaɪ)
(Botany) a saclike structure that produces (usually) eight ascospores during sexual reproduction in ascomycetous fungi such as yeasts and mildews
[C19: from New Latin, from Greek askos bag]

as•cus

(ˈæs kəs)

n., pl. as•ci (ˈæs aɪ, -kaɪ, -ki)
the sac in ascomycetes in which the spores are formed.
[1820–30; < New Latin < Greek askós bag, sac]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.ASCUS - saclike structure in which ascospores are formed through sexual reproduction of ascomycetesascus - saclike structure in which ascospores are formed through sexual reproduction of ascomycetes
reproductive structure - the parts of a plant involved in its reproduction
ascomycete, ascomycetous fungus - any fungus of the class Ascomycetes (or subdivision Ascomycota) in which the spores are formed inside an ascus
Translations

ASCUS

abbr atypical squamous cells of undetermined significance. V. cell.
References in periodicals archive ?
Low reproducibility for ASC-US and LSIL (low grade squamous intraepithelial lesion)
Low-grade squamous intraepithelial lesion and ASC-US were the most-common earlier, abnormal Pap test results: 166 of 978 patients (17.
cytology ASC-US, HPV negative: watch and wait and repeat 1 year
In the case of women found to have ASC-US on cytologic evaluation, the ALTS trial found that HPV testing detected 96.
Rather than immediate colposcopy, adolescents with ASC-US or LSIL on Pap testing should undergo a repeat Pap smear in 12 months.
Another limitation is that approximately 2 million of the 50 million Pap tests performed annually in the United States have equivocal results, which are known as ASC-US.
In total, 361 ASC-US and 415 LSIL cases with corresponding biopsy results and HPV test results were available for dual stain cytology analysis.
The 2001 Bethesda system sought to eliminate the confusion around an ASC-US diagnosis, by better defining criteria, encouraging downgrading to negative for intraepithelial lesion and malignancy (NILM) when possible, and introducing a new atypical category--atypical squamous cells of a high-grade squamous intraepithelial lesion cannot be ruled out (ASC-H).
One of the most significant findings based on the ATHENA study and others, was that an HPV negative result was so reliable in predicting a very low risk that an ASC-US cytology result could more or less be ignored; in effect, the findings indicated that the HPV test trumped the cytology test and the patient could be treated the same as women in the normal screening pool--that is, cytology negative.
The new guidelines do not distinguish between ASC-US and LGSIL in adolescents, because the outcomes of both are similar for these younger women.
1) The hc2 High Risk HPV test has been approved by the Food and Drug Administration for the follow-up evaluation of women with ASC-US (inconclusive) cytology and for use as an adjunctive test combined with the Pap to screen women age 30 years and older.
Interpretation & conclusion: The main utility of HC-II is in the triage of patients with cytology smear diagnosis of ASC-US, ASC-H or L-SIL, for referral to colposcopic examination.