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AZT

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
AZT  (z-t)
n.
A nucleoside analogue antiviral drug that inhibits the replication of retroviruses such as HIV by interfering with the enzyme reverse transcriptase. Also called zidovudine.


AZT
abbreviation for
(Medicine / Pharmacology) azidothymidine Also called zidovudine

AZT  (z-t)
A nucleoside analogue antiviral drug that inhibits the replication of retroviruses such as HIV by interfering with the enzyme reverse transcriptase.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.AZT - an antiviral drug (trade name Retrovir) used in the treatment of AIDS; adverse side effects include liver damage and suppression of the bone marrow
NRTI, nucleoside reverse transcriptase inhibitor - an antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs
Translations
AZT N ABBR =azidothymidineAZT m (medicina antisida)
AZT [ˌeɪzɛdˈtiː] n abbr (=azidothymidine) → AZT f
AZT abbr of azidothymidineAZT nt
AZT [ˌeɪzɛdˈtiː] n abbr =azidothymidineAZT m


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Briefly, some of the liposomes carrying the active substances (lithium and AZT in this particular case) are phagocytized by the macrophages both in the blood circulation and in the HIV sanctuary organs with subsequent lysis and sustained release of the above components.
While AZT and its chemical cousins could delay HIV progression, none of them alone or in 2-drug combinations could durably control HIV, let alone reverse its associated immune suppression and threat of opportunistic diseases.
The picture is different for the four-drug combination AZT + 3TC + abacavir + tenofovir, which is showing good results even though it contains one of the problematic combinations within it.
 
 
 
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