They can be obtained from the respective substituted acetophenones
via the intermediate substituted 1-phenylethylformamides.
The extension of the condensation-cyclization of acetophenones
with other 1,4-dianion-type systems, such as dilihiated acetophenone
phenylhydrazones or carboalkoxyhydrazones, will also be presented.
6,184,417 B1: Bayer AG, Leverkusen, Germany, has patented a method for preparing acetophenones
with a fiuoralkyl-substituted aromatic nucleus.
It behaves as those of [Alpha]-substituted acetophenones
since it undergoes a fast [Beta] cleavage yielding the corresponding benzene sulfonyl and acetophenyl radicals (10).
10:00 Preparation of Dihydroisoxazoles and Dihydropyrazoles from Dilithiated Oximes or Dilithiated Hydrazones and Acetophenones
, Matthew J.