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 (ə-sēt′l-kō′ā′, ăs′ĭ-tl-)
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the hepatic-TG DNL index was also associated with expression of the hepatic lipogenic genes acetyl-Coenzyme A carboxylase alpha (ACACA), fatty acid synthase (FASN), and sterol regulatory element binding transcription factor 1 (SREBP-1), and changes in the expression of these genes were also closely reflected by the VLDL-TG DNL index.
Devoted to naturally occurring metal-carbon bonds, the book sums up recent work in the field, with chapters on organometallic chemistry of B12 coenzymes, cobalamin- and corrinoid-dependent enzymes, nickel-alkyl bond formation in the active site of methyl-coenzyme M reductase, and nickel-alkyl bonds in acetyl-coenzyme A synthases.
In addition, the expression of acetyl-Coenzyme A synthetase 2 (categorized as a "Fatty acid oxidation" gene) was three-fold higher in mammary than liver tissue, consistent with its function of activating acetate for use in ruminant lipid synthesis and fuel support (Smith and Prior, 1986).
Furthermore, theaflavins also inhibited acetyl-coenzyme A carboxylase activities by stimulating AMP-activated protein kinase (AMPK) through the LKB1 and reactive oxygen species pathways.
These acids are made from acetyl-coenzyme A (acetyl-CoA), which is also the starting material for biosynthesis of waxes, flavonoids, certain amino acids and other compounds.