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Treatment with adefovir dipivoxil (Hepsera, Gilead Sciences) both prior to and following liver transplantation in patients with lamivudine-resistant chronic hepatitis B (HBV) infection, significantly improves virologic, biochemical, and clinical parameters, results of an open-label, compassionate use study indicate.
has submitted a Marketing Authorisation Application (MAA) to the European Medicines Evaluation Agency (EMEA) for adefovir dipivoxil 10 mg.
There is no proven treatment for smallpox, but cidofovir and adefovir have shown efficacy in the test tube and in primates.
Adefovir (Preveon) has not been tested in people but seems to have some in vitro efficacy against smallpox.
Adefovir was rejected by the FDA because of severe kidney toxicities coupled with modest efficacy.
Entecavir + Adefovir Versus Lamivudine + Adefovir Or Entecavir Alone In Lamivudine-Resistant Chronic Hepatitis B: 96-Week Data From The DEFINE Study
Other Sigmapharm releases include Liothyronine Sodium Tablets, for hypothyroidism, which is the most stable Liothyronine product on the market with a shelf life of 36 months; Adefovir Dipivoxil Tablets, for hepatitis B, which is the first and only generic product equivalent to Hepsera Tablets; and Sodium Phenylbutyrate Powder, for urea cycle disorders, which is the first and only generic product equivalent to Buphenyl Powder.
4) The primary mutations that confer resistance to the nucleotide analog adefovir (ADV) are rtN236T and/or rtA181T/V.
Clinical performance characteristics have been established for individuals treated with adefovir dipivoxil.
BOSTON -- Tenofovir suppresses viral load more rapidly and effectively than adefovir does in patients with HBe antigen-negative chronic hepatitis B, Dr.
Foster City, CA announced it has submitted a New Drug Application (NDA) to the US Food and Drug Administration (FDA) for marketing approval of adefovir dipivoxil 10 mg.
Drug therapies (lamivudine, entecavir, adefovir, tenofovir, telaprevir, boceprevir, Viread, Myozyme, darbepoetin, symeprewir).
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