This project, undertaken in an international research center and carried out by a talented fellow will provide insights into the mechanisms underlying the regulation of adult neurogenesis
in the normal and injured brain.
Every experiment we did confirmed the close relationship between the immune system and adult neurogenesis
," Beltz said.
The head of the Florey's adult neurogenesis
laboratory, Tim Aumann, said the pilot study could prove the hypothesis that patients who died in winter had fewer dopamine cells in the midbrain and hypothalamus regions, where dopamine is produced.
This process, called adult neurogenesis
, was first discovered by Goldman and Fernando Nottebohm of the Rockefeller University in the early 1980s, when the two realized that when learning new songs new neurons were added to regions of the bird's brain responsible for vocal control.
Specialists in various sciences and medical areas in North America, Europe, Asia, and Saudi Arabia discuss such topics as endoplasmic reticulum stress in the cardiovascular system, the functions of microRNAs in cardiovascular biology and disease, the regulation of insulin secretion in human pancreatic islets, the androgen receptor in health and disease, estrogen and cancer, autophagy and intestinal homeostasis, paneth cells, the impact of adult neurogenesis
on olfactory bulb circuits and computations, the pathophysiology of migraine, the rhythm of breathing, chloride in vesicular trafficking and function, phosphate transporters and their function, and platelets in lung biology.
The beneficial effects of running correlated with increased adult neurogenesis
, which may provide a hint that newborn neurons could be involved in counteracting stress-related disorders.
They cover interactions among sleep-active neurons in the preoptic hypothalamus in the regulation of nonREM sleep, sleep and immune function, genetic approaches to the problem of sleep, the genetics of sleep in Drosophila melanogaster, studies of behavioral quiescence in the nematode Caenorhabditis elegans, identifying the function of sleep by investigating sleep and wakefulness at the molecular level, a model of brain plasticity to explain effects of sleep on adult neurogenesis
, sleep and synaptic homeostasis, growing evidence that sleep is important for learning and memory, and revisiting the ontogenetic hypothesis of rapid eye movement sleep function.
The most active areas of adult neurogenesis
are the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the hippocampal dentate gyms.
In 2007, investigators at Yale University and other institutions formulated a hypothesis that exercise should alleviate the symptoms of MDD by way of adult neurogenesis
Transient expression of doublecortin during adult neurogenesis
Till, presented evidence for adult neurogenesis
in 1963, the older scientific "belief" was relegated to history, and was now pejoratively called "dogma"--something flimsy, merely based on blind, unsound, untrue, and scientifically unprovable assumptions.
An antagonist of estrogen receptors blocks the induction of adult neurogenesis
by insulin-like growth factor-I in the dentate gyrus of adult female rat.