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lovastatin
(redirected from Advicor)

    Also found in: Medical, Wikipedia 0.01 sec.
lo·va·stat·in  (lv-sttn)
n.
A statin, C24H36O5, that blocks the body's synthesis of cholesterol and is administered especially to individuals at risk for heart disease.
[lo-, of unknown origin + -vastatin, statin suff.; see pravastatin.]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.lovastatin - an oral drug (trade name Mevacor) to reduce blood cholesterol levels; used when dietary changes have proved inadequate
Mevacor
lipid-lowering medication, lipid-lowering medicine, statin, statin drug - a medicine that lowers blood cholesterol levels by inhibiting HMG-CoA reductase
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Advicor (niacin extended-release/lovastatin tablets) WARNINGS Skeletal Muscle * Lovastatin ** Potent Inhibitors of CYP3A4 *** Ketolide antibiotic telithromycin added Use of Advicor with other Drugs * Gemfibrozil, particularly with higher doses of lovastatin * Cyclosporine or danazol, with higher doses of lovastatin WARNINGS: Skeletal Muscle/Lovastatin Potent inhibitors of CYP3A4: The risk of myopathy appears to be increased by high levels of HMG-CoA reductase inhibitory activity in plasma.
Safety labeling changes approved by CDER--April 2007 by Adverse Event Reporting News
Specifically, the inspection revealed deviations in the firm's Quality and Laboratory systems employed during the manufacture, processing, packing and holding of Niaspan (niacin extended-release tablets) and Advicor (niacin extended-release tablet cores/lovastatin tablets).
Human drugs by Warning Letter Bulletin
29 letter, the focus of FDA's July-August 2003 follow-up audit was Kos' quality and laboratory systems employed during the manufacture, processing, packing and holding of Niaspan (niacin extended-release tablets) and Advicor (niacin extended-release tablet cores/lovastatin tablets).
Agency says Kos repeated Quality Control violations by Gould, Dawn / Validation Times
 
 
 
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