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Aganglionic

   Also found in: Medical 0.03 sec.
A`gan`gli`o´nic
a.1.(Physiol.) Without ganglia.


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Sustained contraction of the aganglionic bowel is the main pathophysiologic feature of this disease, resulting in functional bowel obstruction in the newborn.
Absence of NADPH-diaphorase activity has been reported in the aganglionic colon in patients with Hirschsprung disease, and absent or reduced NADPH-diaphorase activity was reported in the nerves within the hypertrophied circular muscle in patients with pyloric stenosis.
[10] Hirschsprung disease (HD) is a disorder of intestinal innervation in which the 2 principal histologic features are the absence of ganglion cells and the presence of increased numbers of hypertrophic nerve bundles in the aganglionic segment of bowel.
 
 
 
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