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agranulocytosis

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
a·gran·u·lo·cy·to·sis  (-grny-l-s-tss)
n.
An acute disease marked by high fever and a sharp drop in circulating granular white blood cells. It may be drug-induced or the result of exposure to radiation.

agranulocytosis [əˌgrænjʊləʊsaɪˈtəʊsɪs]
n
(Medicine / Pathology) a serious and sometimes fatal illness characterized by a marked reduction of leucocytes, usually caused by hypersensitivity to certain drugs
[New Latin; see a-1, granule, -cyte, -osis]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.agranulocytosis - an acute blood disorder (often caused by radiation or drug therapy) characterized by severe reduction in granulocytes
blood disease, blood disorder - a disease or disorder of the blood


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WARNINGS Serious Dermatologic Reactions SJS/TEN and HLA-B*1502 Allele Aplastic Anemia and Agranulocytosis Patients with a history of adverse hematologic reaction to any drug may be particularly at risk of bone marrow depression.
1) Unfortunately, carbamazepine can be a difficult medication to use, due to significant drug-drug interactions, laborious titration related to enzyme autoinduction (both due to induction of the cytochrome P450 system), potential for agranulocytosis and hyponatremia.
Overall, it was concluded that a change to monthly monitoring after a year in patients with normal counts would not significantly increase the risk of agranulocytosis and would be favorable to the patient in terms of convenience and discomfort from repeated venipuncture," he told this newspaper.
 
 
 
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