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Related to Alkylating agents: Antimetabolites


tr.v. al·kyl·at·ed, al·kyl·at·ing, al·kyl·ates
To add one or more alkyl groups to (a compound).

al′kyl·a′tion (-kə-lā′shən) n.


1. (Chemistry) the attachment of an alkyl group to an organic compound, usually by the addition or substitution of a hydrogen atom or halide group
2. (Chemistry) the addition of an alkane hydrocarbon to an alkene in producing high-octane fuels


(ˌæl kəˈleɪ ʃən)

1. the replacement of a hydrogen atom in an organic compound by an alkyl.
2. the addition of an alkane to an alkene.
References in periodicals archive ?
alkylating agents, antimetabolites, radiation or large doses of
The Measles vaccine is not recommended (contraindicated) for persons with congenital immunodeficiency, HIV infection, leukaemia, lymphoma or generalised malignancy or those who are currently receiving alkylating agents, antimetabolites, radiation or large doses of corticosteroids, in addition to pregnant women.
Four of the SPM patients received either alkylating agents and/or immunomodulators during MM treatment, but the other two patients received only bortezomib plus dexamethasone (BD) therapy before SPM was diagnosed.
For example, many alkylating agents, such as cyclophosphamide and ifosfamide, are notorious for causing transient or permanent azoospermia.
Immunosuppressant drugs include antimetabolites, alkylating agents, some antibiotics and specific adjuvants.
Alkylating agents, for example, are more likely to contribute to the development of leukemia than cisplatin or carboplatin.
Besides corticosteroids, long-term treatment options for the treatment of JIA-associated uveitis include antimetabolites, alkylating agents and biologic agents.
1) Patients with therapy-related acute leukemias from alkylating agents generally show a latency of 3-7 years from exposure to the alkylating agent and often have an insidious course, with the development of MDS prior.
Exposure to multiagent chemotherapy, particularly alkylating agents, may potentiate the effect of previous radiation therapy in childhood and thus serve as another predisposing factor for the development of a postradiation sarcoma [12].
The major medications used for chemotherapy include various combinations of the following agents: the immunomodulators thalidomide and lenalidomide; the proteasome inhibitor bortezomib; the alkylating agents melphalan and cyclophosphamide; and the steroids dexamethasone and prednisone.
This is especially true for women who may be receiving gonadotoxic therapies, such as alkylating agents or abdominal/pelvic radiation.
He begins with the reagents and processes: alkylating agents, acylating agents, nitration and nitrosylation, oxidation, and modifying proteins with reducing agents.