A study from Boston Children's Hospital, Brigham and Women's Hospital and Harvard Medical School supports a surprising alternative approach to controlling asthma: targeting certain sensory nerve endings in the lungs that help drive allergic inflammation
In this proposal, we will address the role of extracellular miRNAs for the normal T cell development and during allergic inflammation
of the airways.
In murine models of allergic inflammation
, IFN-[gamma] has been shown to prevent the development of antigen-induced airway eosinophilia and hyper-responsiveness.
Animal studies have shown that a maternal diet rich in methyl donors can enhance susceptibility to allergic inflammation
in the offspring, mediated through increased DNA methylation.
Interestingly, the animals showed considerable reduction in the allergic inflammation
response to dust mite extract and created immune cells that were less capable of prompting inflammatory responses in airways.
caused by inappropriate immune responses to some types of food has become a major public health issue.
This increased gene expression matters because it can cause white blood cells called mononuclear cells to produce far greater amounts of inflammatory factors like interleukin 4, LIGHT and lymphotoxin beta receptor which contribute to allergic inflammation
and other abnormalities in the bronchial passages in asthma.
This opens the door for new ways to look at bacterial-associated allergic inflammation
," says John Wherry, an associate professor of microbiology at the University of Pennsylvania, Philadelphia.
Furthermore we show in an acute model of allergic airway disease that following sensitization without adjuvant and challenge of the mice, treatment with medicinal plant extracts inhibits the development of allergic inflammation
DP2, also known as chemoattractant receptor-homologous molecule expressed in Th2 lymphocytes (CRTH2), is a high affinity receptor for the prostaglandin D2 and is implicated in humans in Th2-dependent allergic inflammation
Undoubtedly, the emissions coming from diesel generators can cause health problems including bronchial allergic inflammation
, acute bronchitis and emphysema," he said.
Summary: LOS ANGELES, July 06, 2010, SPA -- Brief exposure to ultra fine pollution particles near a Los Angeles freeway can boost the allergic inflammation
that makes asthma worse, U.