The researchers found that cardiolipin -- a molecule inside nerve cells -- helps ensure that a protein called alpha-synuclein
They found that calcium can mediate the interaction between small membranous structures inside nerve endings, which are important for neuronal signalling in the brain, and alpha-synuclein
, the protein associated with Parkinson's disease.
SAN DIEGO -- The presence of Corynebacterium in the gut microbiome of people with two G alleles at the rs356219 single nucleotide polymorphism locus of the alpha-synuclein
gene was associated with 100% probability of having Parkinson's disease in a study conducted by the NeuroGenetics Research Consortium.
The company has invested in building a strong R and D team for executing its current and future pipeline development, including a 3rd generation tau PET imaging tracer, alpha-synuclein
PET imaging tracer, and two distinctive therapeutic programs.
Objective: To elucidate the genetic risk and role of alpha-synuclein
gene in the pathogenesis of Parkinson's disease in Pakistani population.
The topics include protein quality control in health and disease, the HET-S/s prion motif in the control of programmed cell death, cross-beta polymerization of low complexity sequence domains, neurodegenerative disease transmission and transgenesis in mice, potential pathways of abnormal tau and alpha-synuclein
dissemination in sporadic Alzheimer's and Parkinson's diseases, and aggregation and prion-like properties of misfolded tumor suppressors: whether cancer is a prion disease.
However, a protein called alpha-synuclein
becomes damaged or exhibits abnormalities in particular areas of the brain, which leads in turn to nerve cell damage," explains Dr.
The product is an alpha-synuclein
antibody presently in development as a potential treatment for Parkinson's disease.
1997) Mutation in the alpha-synuclein
gene identified in families with Parkinson's disease.
In Parkinson's, alpha-synuclein
behaves much like Tau in Alzheimer's," said study lead research Keqiang Ye, in a (https://www.
While findings can lead to new treatments to decrease alpha-synuclein
levels, researchers say continuing treatment with L-Dopa, which replenishes doparnine in the brain, remains standard care.
AFFiRiS AG called upon the Qatar-based team to use the tools and expertise developed at HBKU to validate the target engagement of alpha-synuclein
for the company's first-of-its-kind Parkinson's disease immunotherapy approach.