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 (ăl′fə-sĭ-no͞o′klē-ĭn, -nyo͞o′-)
A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.
References in periodicals archive ?
The researchers found that cardiolipin -- a molecule inside nerve cells -- helps ensure that a protein called alpha-synuclein folds properly.
They found that calcium can mediate the interaction between small membranous structures inside nerve endings, which are important for neuronal signalling in the brain, and alpha-synuclein, the protein associated with Parkinson's disease.
SAN DIEGO -- The presence of Corynebacterium in the gut microbiome of people with two G alleles at the rs356219 single nucleotide polymorphism locus of the alpha-synuclein gene was associated with 100% probability of having Parkinson's disease in a study conducted by the NeuroGenetics Research Consortium.
The company has invested in building a strong R and D team for executing its current and future pipeline development, including a 3rd generation tau PET imaging tracer, alpha-synuclein PET imaging tracer, and two distinctive therapeutic programs.
Objective: To elucidate the genetic risk and role of alpha-synuclein gene in the pathogenesis of Parkinson's disease in Pakistani population.
The topics include protein quality control in health and disease, the HET-S/s prion motif in the control of programmed cell death, cross-beta polymerization of low complexity sequence domains, neurodegenerative disease transmission and transgenesis in mice, potential pathways of abnormal tau and alpha-synuclein dissemination in sporadic Alzheimer's and Parkinson's diseases, and aggregation and prion-like properties of misfolded tumor suppressors: whether cancer is a prion disease.
However, a protein called alpha-synuclein becomes damaged or exhibits abnormalities in particular areas of the brain, which leads in turn to nerve cell damage," explains Dr.
The product is an alpha-synuclein antibody presently in development as a potential treatment for Parkinson's disease.
1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
In Parkinson's, alpha-synuclein behaves much like Tau in Alzheimer's," said study lead research Keqiang Ye, in a (https://www.
While findings can lead to new treatments to decrease alpha-synuclein levels, researchers say continuing treatment with L-Dopa, which replenishes doparnine in the brain, remains standard care.
AFFiRiS AG called upon the Qatar-based team to use the tools and expertise developed at HBKU to validate the target engagement of alpha-synuclein for the company's first-of-its-kind Parkinson's disease immunotherapy approach.