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 (ăl′fə-fē′tō-prō′tēn, -tē-ĭn)
n. Abbr. AFP
A glycoprotein that is abundant in the blood plasma of human and other mammalian fetuses and is also present in the serum of people with certain diseases, such as liver cancer. Abnormal levels in maternal serum are associated with certain fetal abnormalities, including Down syndrome and spina bifida.


(Biochemistry) a protein that forms in the liver of the human fetus. Excessive quantities in the amniotic fluid and maternal blood may indicate spina bifida in the fetus; low levels may point to Down's syndrome. Abbreviation: afp


(ˌfi toʊˈproʊ tin, -ti ɪn)

a serum protein produced during pregnancy, useful in the prenatal diagnosis of multiple births or birth defects. Abbr.: AFP
References in periodicals archive ?
Laboratory tests, including serum alphafetoprotein (aFP) and beta-human chorionic gonadotropin (HCG) levels, were within normal limits.
5) Alphafetoprotein (AFP) has been shown to be reliable indicator of disease activity and some authors advocate investigating teratoma recurrence by doing serial serum AFP levels.
All patients in the liver cohort underwent abdominal ultrasound, standard liver function tests (LFTs), detailed screening of secondary causes of liver disease, HA level, platelet count, and alphafetoprotein measurements.
Wako Diagnostics, a division of Wako Chemicals USA, received 510(k) clearance from the FDA to market the [mu] TASWako i30 instrument with alphafetoprotein L3 (AFP-L3) and des-gamma-carboxy prothrombin (DCP) in vitro diagnostic (IVD) tests in the U.
However this observation may require clarification, since other authors report increases in serum alphafetoprotein for both hepatocellular carcinoma and cholangiocarcinoma in dogs.
Maternal serum alphafetoprotein assay using ELISA in normal pregnancy.
Detection of hepatocellular carcinoma with a new alphafetoprotein antibody imaging kit.
Screening for trisomy 18 has been in practice since the 1980s, when unconjugated estriol (uE3) and human chorionic gonadotropin (hCG) were added to the measurement of alphafetoprotein (AFP) as part of second trimester serum maternal screening protocols for Down syndrome.
Serum alphafetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HbsAg and anti-HCV status.
One is a "triple test," in which the mother's blood is drawn during the first trimester of pregnancy and tested for levels of alphafetoprotein and two other substances that indicate the presence of Down syndrome.