areg

(redirected from Amphiregulin)
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areg

(əˈrɛɡ)
n
(Physical Geography) a plural of erg2
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The discovery that both estrogen and progesterone must be present for the increased production of the protein amphiregulin, which binds to mammary cells and promotes cell growth, could lead to new treatment methods for the disease, said Sandra Haslam, director of Michigan State University's Breast Cancer and the Environment Research Center and lead researcher on the project.
Gene expression profiles showed that patients with tumours that express high levels of the EGFR ligands epiregulin and amphiregulin are more likely to have disease control with cetuximab.
Other known EGFR family ligands (13) like heregulin-[alpha] (HRG-[alpha]), heregulin-[beta] (HRG-[beta]), transforming growth factor--[alpha] (TGF-[alpha]), betacellulin (BC) and amphiregulin (AR) did not show any significant blast hits (Table 3).
Sheddase activity is also responsible for the release of the active forms of EGFR ligands and we have seen reductions in the circulating levels of the EGFR ligands TGFa, heregulin and amphiregulin, suggesting that INCB7839 is indeed inhibiting signaling through all four EGFR-family receptors.
Primer sequences and PCR product sizes of genes selected for validation by RT Gene GenBank ID [beta]-actin SSU07786 Amphiregulin AREG AY028311.
There is evidence that the EGFR ligands epiregulin and amphiregulin are important for prediction of response to cetuximab.