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| All of the following are Amsterdam criteria for the diagnosis of the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome except: The classic Amsterdam criteria (12) were the first developed to support the diagnosis of HNPCC. 20) The Amsterdam criteria are considered inadequate to address the whole picture of HNPCC in two aspects: (1) extracolonic tumors are not included and (2) cases with limited family history are inappropriately excluded. |
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