amyloid precursor protein


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Related to amyloid precursor protein: amyloidosis, Tau protein

amyloid precursor protein

n. Abbr. APP
A protein found in cell membranes that forms beta-amyloid fragments when cleaved by the secretase designated beta.
References in periodicals archive ?
IL-1B, thought to increase amyloid precursor protein and promote tau phosphorylation, increased by 109%.
Amyloid precursor protein (APP) severing disorder lead to over expression or less clearance of A[beta], and then A[beta] became aggregated.
Merck is evaluating verubecestat (MK-8931) an investigational small molecule inhibitor of the beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), in a Phase 3 study of people with prodromal AD (APECS).
The study assessed verubecestat, an investigational small molecule inhibitor of the beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), in people with mild-to-moderate Alzheimer's disease.
Molecular mechanism of Amyloid Precursor Protein (APP) processing
One thing that scientists on both sides of the beta-amyloid debate have noticed is that beta-amyloid has what amounts to a sister protein: amyloid precursor protein intra cellular domain, or AICD.
Because the amyloid precursor protein gene is also over-expressed in Down syndrome, these patients accumulate beta-amyloid at a greatly accelerated rate and will, inevitably, develop Alzheimer's dementia.
The A[beta] peptide is a cleavage product of amyloid precursor protein (APP) by sequential action of [beta]- and [gamma]-secretases which release 39-43-amino- acid peptide from the C-terminal (cytoplasmic) end of transmembrane protein [6].
People with Down syndrome are born with an extra copy of chromosome 21, which contains the amyloid precursor protein gene.
It is generated when the considerably larger amyloid precursor protein, or APP, is cleaved.
Molecular evidences show that HSV-1 infection of neuronal and glial cells results in the formation of the characteristic abnormal molecule of AD ([alpha]-amyloid) and a decrease of the amyloid precursor protein (APP).
Cleavage of the amyloid precursor protein (APP) generates varying lengths of A3 peptides (38-43 amino acids) that accumulate in the extracellular space.