Other advantages include the ability to identify difficult-to-culture organisms such as obligate anaerobes
that constitute a serious, and increasing, medical problem.
The abstract explains, "96-99% of the 'friendly' or residential micro flora found in the intestinal tract of humans consists of strict anaerobes
and only 1-4% of aerobes.
The most common pathogens cited are aerobes and facultative anaerobes
that include Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Moraxella catarrhalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and S.
Then we had to standardize the enzyme system and formulate a product to perform under conditions needed to grow anaerobes
diphtheroids, streptococci, anaerobes
, yeast, and fungi.
At hospital discharge and at 60 days after discharge, oligofructose-treated patients carried significantly higher concentrations of fecal bifidobacteria and total anaerobes
, but not aerobes, compared with placebo-group patients.
have increasingly been recognized in the pathology of osteomyelitis.
Wyeth is seeking market approval for Tygacil as a single agent therapy to treat patients with complicated intra-abdominal infections (cIAI) and complicated skin and skin structure infections (cSSSI), caused by gram-negative and gram-positive pathogens, anaerobes
, and both methicillin-susceptible and methicillin-resistant strains of Staphylococcus aureus (MSSA and MRSA).
Further, given that 25% of moxifloxacin is excreted through the intestinal tract (Avelox package insert), the use of moxifloxacin for respiratory infections exposes bacteria in the intestinal tract to a fluoroquinolone with greater activity against Bacteroides fragilis and other intestinal anaerobes
than levofloxacin (29,30).
The new quinolones include 1evofloxacin, which is considered a secondgeneration drug; gatifloxacin, a third-generation agent with improved activity against gram-positive and atypical pneumonia pathogens; and moxifloxacin and gemifloxacin, fourth-generation quinolones that have even better gram-positive activity and "reasonable" activity against gram-negative bacteria, anaerobes
, and atypical pathogens, said Dr.
Feeding on the by-products of their metabolism is a mid-level community of anaerobes
Poster # 3460: "Activity of a Novel Cationic Steroid Antimicrobial (CSA-13) Targeting Aerobic and Facultative Gram-negative Bacilli, Gram-Positive Anaerobes
and Select Agent Surrogate Strains";