(redirected from Androgen antagonist)
Also found in: Medical.


 (ăn′tē-ăn′drə-jən, ăn′tī-)
A substance that inhibits the biological effects of androgenic hormones.
References in periodicals archive ?
Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist.
Other forms of therapy include androgen antagonist drugs such as ketoconazole, finasteride and insulin-sensitizing drugs such as metformin.
Low-level exposure to endocrine-disrupting compounds can induce functional, developmental, behavioral, and transgenerational disturbances, as shown after low-level exposure to the fungicide vin-clozolin, which acts as an androgen antagonist in rats and mice (Anway et al.
This new drug is the latest breakthrough for the treatment of advanced cases and is the first-in-class intracrine androgen antagonist for patients whose cancer has stopped responding to androgen deprivation therapy (ADT).
The objectives of the first phase of the OECD validation of the Hershberger bioassay were to a) demonstrate the reproducibility and sensitivity of the responses of five male sex accessory tissues to the action of a reference androgen, TP, hereafter phase 1A; b) assess the utility, reproducibility, and sensitivity of various other measured end points within and among participating laboratories in response to the action of TP; c) study the interaction of reference TP doses with a reference androgen antagonist, FLU, on the sex accessory tissues and other end points, hereafter phase 1B; and d) select standard reference doses of TP and FLU for future studies with weakly potent agonists, antagonists, and nonandrogenic test substances.
18) Low androgen levels, such as in those who are androgen deficient or using androgen antagonists, can result in reduced quality and quantity of meibomian lipids which is seen clinically as increased tear film instability and reduced tear break-up time (TBUT).
All test systems showed that bicalutamide and hydroxyflutamide act as potent androgen antagonists (Ma et al.
This modified system was successfully used by several investigators for assaying androgen antagonists (Peers et al.
Calculated properties of dihydrotestosterone (DHT) in relation to fenitrothion and known androgen antagonists.