antimetabolite

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Related to Anti-metabolite: methotrexate

an·ti·me·tab·o·lite

 (ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)
n.
A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.

an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.

antimetabolite

(ˌæntɪmɪˈtæbəˌlaɪt)
n
(Pharmacology) any drug that acts by disrupting the normal growth of a cell. Sulfonamide drugs are antimetabolites and some antimetabolites are used in cancer treatment

an•ti•me•tab•o•lite

(ˌæn ti məˈtæb əˌlaɪt, ˌæn taɪ-)

n.
any substance that interferes with growth by competing with a nutrient metabolite for receptors or enzymes in the body, used esp. for treating certain cancers.
[1940–45]
an`ti•met`a•bol′ic (-ˌmɛt əˈbɒl ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
fluorouracil - an antimetabolite used to treat certain cancers
mercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
amethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
References in periodicals archive ?
Taiho Pharmaceutical's TS-1 is a combination chemotherapy that consists of tegafur (a pro-drug of 5-FU) and two agents, gimeracil and oteracil, which decrease the rate of degradation of the 5-FU anti-metabolite.
RX-3117 is a novel small molecule anti-metabolite compound that inhibits DNA and RNA synthesis and induces apoptotic cell death of tumour cells.
5FU is an anti-metabolite and blocks DNA synthesis as well as is incorporated into RNA and DNA.

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