antimetabolite

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Related to Antimetabolites: topoisomerase inhibitors, plant alkaloids

an·ti·me·tab·o·lite

 (ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)
n.
A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.

an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.

antimetabolite

(ˌæntɪmɪˈtæbəˌlaɪt)
n
(Pharmacology) any drug that acts by disrupting the normal growth of a cell. Sulfonamide drugs are antimetabolites and some antimetabolites are used in cancer treatment

an•ti•me•tab•o•lite

(ˌæn ti məˈtæb əˌlaɪt, ˌæn taɪ-)

n.
any substance that interferes with growth by competing with a nutrient metabolite for receptors or enzymes in the body, used esp. for treating certain cancers.
[1940–45]
an`ti•met`a•bol′ic (-ˌmɛt əˈbɒl ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
fluorouracil - an antimetabolite used to treat certain cancers
mercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
amethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
References in periodicals archive ?
alkylating agents, antimetabolites, radiation or large doses of
The Measles vaccine is not recommended (contraindicated) for persons with congenital immunodeficiency, HIV infection, leukaemia, lymphoma or generalised malignancy or those who are currently receiving alkylating agents, antimetabolites, radiation or large doses of corticosteroids, in addition to pregnant women.
Browse Non-Small Cell Lung Cancer (NSCLC) Therapeutics Market by Drug Classes (Angiogenesis Inhibitors - Avastin, Cyramza; Epidermal Growth Factor Receptor Blockers - Tarceva, Gilotrif, Iressa; Folate Antimetabolites - Alimta; Kinase Inhibitors - Xalkori, Zykadia; Microtubule Stabilizers - Abraxane, Docetaxel; and PD-1/ PD-L1 Inhibitors - Opdivo, Keytruda), and Clinical Pipeline Analysis of Phase 1, 2 and 3 Drugs (Avelumab, MPDL3280A, MEDI4736, Abemaciclib) and Forecast 2017-2021 at https://www.
Methotrexate (MTX) is an antifolate subclass of antimetabolites.
All patients received initial immunosuppres-sive therapy with prednisolone (P), antimetabolites (mycophenolatemofetil-(MMF), azathioprine-(AZA)) combined with calcineurin inhibitors (CNI; cyclosporin A-CyA/, tacrolimus-Tac), interleukin-2 receptor antagonists (IL-2ra) or mechanistic target of rapamycin (mTOR) inhibitors (sirolimus(SRL)/ everolimus (EVL)).
Radiotherapy, antimetabolites, and conjunctival limbal autograft have been proposed for treating recurrent pterygium.
24) However, all of these antimetabolites take a month to several months to achieve a therapeutic effect and are associated with undesirable side effects.
A successful case of trabeculectomy without adjunctive antimetabolites performed with retrobulbar anesthesia has been reported in a pregnant patient.
Other drugs associated with GVHD-like features (increased crypt apoptosis, cystically dilated crypts lined by flattened and degenerated epithelium and luminal apoptotic debris) include antimetabolites (methotrexate, capecitabine), and tumor necrosis [alpha] inhibitors (etanercept and infliximab).
human immunodeficiency virus [HIV] infection or acquired immune deficiency syndrome [AIDS], leukemia, lymphoma, generalized malignancy, solid organ transplantation, or therapy with alkylating agents, antimetabolites, radiation, tumor necrosis factor [TNF] inhibitors, or high-dose corticosteroids [[greater than or equal to] 2 mg/kg body weight or [greater than or equal to]20 mg/day of prednisone or its equivalent for [greater than or equal to]2 weeks], hematopoietic stem cell transplant recipients <24 months post-transplant or [greater than or equal to]24 months, but who have graft-versus-host disease or disease relapse, or autoimmune disease [e.
Besides corticosteroids, long-term treatment options for the treatment of JIA-associated uveitis include antimetabolites, alkylating agents and biologic agents.