antimetabolite

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Related to Antimetabolites: topoisomerase inhibitors, plant alkaloids

an·ti·me·tab·o·lite

 (ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)
n.
A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.

an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.

antimetabolite

(ˌæntɪmɪˈtæbəˌlaɪt)
n
(Pharmacology) any drug that acts by disrupting the normal growth of a cell. Sulfonamide drugs are antimetabolites and some antimetabolites are used in cancer treatment

an•ti•me•tab•o•lite

(ˌæn ti məˈtæb əˌlaɪt, ˌæn taɪ-)

n.
any substance that interferes with growth by competing with a nutrient metabolite for receptors or enzymes in the body, used esp. for treating certain cancers.
[1940–45]
an`ti•met`a•bol′ic (-ˌmɛt əˈbɒl ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
fluorouracil - an antimetabolite used to treat certain cancers
mercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
amethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
References in periodicals archive ?
Browse the full Non Small Cell Lung Cancer Therapeutics Market: (By Drug Class: Angiogenesis Inhibitor, EGFR Inhibitor, Kinase Inhibitor, Microtubule Stabilizer, Folate Antimetabolites, and PD-1/PD-L1 Inhibitor): Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2015 - 2023 report at http://www.
Antimetabolites Aminopterin * + + / [+ or -] + Azathioprine 0 0 5-fluorouracil * + + + / + + + Methotrexate * + + / [+ or -] 0 Thioguanine + + No activity shown by cytarabine, mercaptopurine.
Modufolin (chemical name [6R]-5,10- methylenetetrahydrofolate), is a novel folate-based compound developed to increase the efficacy and reduce the side effects of antimetabolites used in cancer treatment.
These studies indicate that TGF-[beta]2 may naturally modify the antiscarring effects of antimetabolites in glaucoma filtration surgery (Cordeiro et al.
The use of these drugs during pregnancy has been a concern, because they are cytotoxic antimetabolites that are also used as anticancer drugs, albeit at higher doses than those used for IBD.
In our patient, we were concerned that haemolysis due to DDS in the presence of bone marrow depression caused by the antimetabolites (the levels of which were unavailable at the time), could be catastrophic.
One of a group of chemotherapy drugs known as antimetabolites, it prevents cells from making DNA and RNA - ribonucleic acid - which causes cells to die.
Other topics of the 66 chapters include topoisomerase inhibitors, antimetabolites, cytokines, monoclonal antibodies, biophosphonates, anemia, metabolic emergencies, and pain management.
Antimetabolites are substances that are chemically very similar to the building blocks of DNA and RNA--purine and pyrimidine.
congenital immunodeficiency, HIV infection [vaccinate as close to diagnosis as possible when CD4 cell counts are highest], leukemia, lymphoma, multiple myeloma, Hodgkin disease, generalized malignancy, or organ or bone marrow transplantation); chemotherapy with alkylating agents, antimetabolites, or long-term systemic corticosteroids; and cochlear implants.
Antimetabolites are a broad class of drugs that interferes with the basic metabolism of cancer cells.
5) Current therapy involves the use of combinations of steroids (topical, oral, and IV), antimetabolites, and cytotoxic medications.