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apoptosis |
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| By impairing the development of adaptive immune responses needed for recovery, the apoptotic destruction of lymphocytes and dendritic cells could have a particularly adverse effect on disease outcome. In addition, we used reverse-transcriptase polymerase chain reaction and Western blotting to demonstrate significantly increased levels of the apoptotic effecter caspase-3 in treated animal hearts. In animal models, histologic findings resemble apoptotic cell death rather than necrosis. |
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