Traditionally, scientists thought that star-shaped brain cells called astrocytes
were steady, quiet supporters of their talkative, wire-like neighbors, called neurons.
For multiple sclerosis, specifically, increasing cholesterol synthesis gene expression in astrocytes
of the spinal cord can be a pathway to repair nerves that affect walking.
Researchers led by the University of Edinburgh generated brain cells called astrocytes
from induced pluripotent stem cells, which are non-specialized cells that can transform into other cell types.
June 6, 2017 -- Neurons are preeminently important to the central nervous system, of course, but the star-shaped support cells called astrocytes
are gaining greater prominence.
June 6, 2017-Neurons are preeminently important to the central nervous system, of course, but the star-shaped support cells called astrocytes
are gaining greater prominence
are the most abundant cells among the three cell types derived from NSCs (2) and reside throughout the entire central nervous system (CNS), playing important roles in brain development and function.
amp;nbsp;Researchers at the Marche Polytechnic University in Italy, led by Michele Bellesi, found that a type of cells in the brain, called astrocytes
, go into overdrive in mice that are sleep deprived.
Our findings indicate that the hGFAP promoter contains matching regulatory elements for directing specific expression in porcine astrocytes
Recent studies have supported the hypothesis that astrocytes
have a beneficial role contributing to amyloid-beta clearance, but also that excess amyloid-beta can lead to oxidative stress and damage, and as a consequence to reduced astrocyte
functionality, leading to reactive changes and decreased neuronal support, and thereby contributing to neurodegeneration.
The findings of the researchers, who monitored several pathological changes in the brain, suggest that activation of astrocytes
at an early stage can greatly influence the development of the disease.
Pastor, "Plasma albumin induces cytosolic calcium oscilations and DNA synthesis in human cultured astrocytes
," BioMed Research International, vol.
comprise the most numerous type of cell in the brain and play a crucial role in neuronal homeostasis both for normal physiologic functioning and in response to cell stress .