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autoimmunity
(redirected from Autoantigens)

   Also found in: Medical, Encyclopedia, Wikipedia 0.01 sec.
au·to·im·mune  t--myn)
adj.
Of or relating to an immune response by the body against one of its own cells or tissues.

auto·im·muni·ty n.
auto·immu·ni·zation (-my-n-zshn) n.
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.autoimmunity - production of antibodies against the tissues of your own body; produces autoimmune disease or hypersensitivity reactions
autoimmune disease, autoimmune disorder - any of a large group of diseases characterized by abnormal functioning of the immune system that causes your immune system to produce antibodies against your own tissues
pathology - any deviation from a healthy or normal condition


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Methods: Immortalized human salivary acinar cell line NS-SV-AC cells were incubated with EGCG (epigallocat-echin-3 gallate), the most abundant GTP, prior to determination of expression changes in major autoantigens by microarray, RT-PCR and Western analysis.
The peptide, now called MBP8298, targets a particular stretch of amino acids of human myelin basic protein (MBP), a major structural protein of myelin that is one of the candidate autoantigens in MS.
The reacting IgG class antibody, which was purified from normal human serum by affinity chromatography on bupleuran 2IIc (a pharmacologically active pectic polysaccharide from the roots of Bupleurum falcatum)-immobilized Sepharose, showed cross-reactivity not only with some other pharmacologically active pectic polysaccharides from other medicinal herbs but also with autoantigens such as single-strand DNA, myosin and tublin from mammals.
 
 
 
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