autophagy

(redirected from Autophagolysosome)
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Related to Autophagolysosome: Autophagocytosis

au·toph·a·gy

 (ô-tŏf′ə-jē)
n.
The process of self-digestion by a cell through the action of enzymes originating within the same cell.

autophagy

(ɔːˈtɒfədʒɪ) or

autophagia

n
the consumption of one's own tissue by biting oneself

autophagy, autophagia

Medicine. 1. the eating of one’s own body.
2. the nutrition of the body by its own tissues, as in dieting. — autophagous, adj.
See also: Food and Nutrition
References in periodicals archive ?
The autophagosome, a double membrane structure containing engulfed cytoplasm and its organelle content, fuses with lysosome(s) to create an autophagolysosome within which the endocytosed contents can be degraded by lysosomal enzymes.
Autophagy, as a dynamic process, might be divided into few stages including (i) induction of the process, (ii) autophagosome formation, (iii) autophagolysosome formation, and (iv) delivery and degradation of the autophagic body.
Another regulator of the autophagolysosome formation is the PLEKHM1, (pleckstrin homology domain containing protein family member 1) which controls the fusion through binding to LC3 and HOPS (homotypic fusion and protein sorting) complex, as genetic loss of PLEKHM1 leads to an impaired autophagosome-lysosome fusion [117].