BRCA


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BRCA

n.
Either of two tumor suppressor genes (BRCA1 or BRCA2) that are associated with an increased risk of developing familial breast and ovarian cancer when inherited in a mutated state.

[br(east) ca(ncer).]
References in periodicals archive ?
The test only detects three out of more than 1,000 known BRCA mutations.
The Food and Drug Administration approved AstraZeneca PLC's Lynparza for patients with inherited BRCA gene mutations who have undergone chemotherapy, the FDA said in a statement.
Cancer information company ACT Genomics said on Thursday that it has agreed for both somatic and germline genetic testing of BRCA in patients with ovarian cancer with the advanced next generation sequencing (NGS) technology in Singapore and Taiwan in collaboration with AstraZeneca Singapore.
Currently, young women with breast cancer and a BRCA mutation frequently are offered bilateral mastectomy, the authors noted.
Domchek, executive director of the Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania, and national leader on the OlympiAD trials.
The results of 558 of the women, who had the rare triple-negative breast cancer, suggest that those with BRCA mutations have similar survival chances to those without, at five and 10 years after diagnosis.
Women diagnosed with early breast cancer who carry a BRCA mutation are often offered double mastectomies soon after their diagnosis or chemotherapy treatment" compared to non-mutation carriers, study co-author Diana Eccles of the University of Southampton said in a statement.
Mutations in the BRCA gene are associated with several forms of cancer, including breast, ovarian and prostate cancers.
BRCA genes are part of the body's natural defence system and help protect from developing certain types of cancer.
Of those diagnosed with ovarian cancer, only 29 per cent are offered BRCA (BReast CAncer susceptibility) testing, which could inform their treatment and enable them to warn other family members who may also be at risk from the faulty gene.
Holtz's interest in my commentary on the role of hysterectomy as part of risk-reducing surgery in BRCA mutation carriers.
To learn how the NEXTflex BRCA1 and BRCA2 Amplicon Panels can improve Illumina or Ion Torrent-based BRCA analysis, visit www.