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BRCA1

   Also found in: Medical, Acronyms, Encyclopedia, Wikipedia 0.03 sec.
BRCA1
n.
A gene that is associated with the development of familial breast cancer when inherited in a defective state.
[br(east) ca(ncer) 1.]


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Since its discovery in 1994, the BRCA1 gene has given up its secrets grudgingly.
Cancer link: gene regulates progesterone effect on breast cells by Seppa, Nathan / Science News
The oncogenes c-myc, c-met, k-ras and the neoplastic progression protein-3 (Npn3) were also increased 2- to 3-fold in arsenic-induced HCC and nontumorous, normal liver from arsenic exposed mice, while the tumor suppressors BRCA1 and BRCA2 decreased 30-50%.
Global gene expression associated with hepatocarcinogenesis in adult ... by Waalkes, Michael P. / Environmental Health Perspectives
1) In a multicenter case-control study, women with a BRCA1 mutation who were ever-users of oral contraceptives had 20% higher odds of having had breast cancer than never-users.
Some women with genetic susceptibility to breast cancer face elevated ... by London, S. / Perspectives on Sexual and Reproductive Health
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