Bence-Jones protein


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Bence-Jones protein

 (bĕns′jōnz′)
n.
A protein occurring in the serum and urine of patients with certain diseases, especially multiple myeloma.

[After Henry Bence-Jones (1813-1873), British physician.]
References in periodicals archive ?
Urinary Bence-Jones protein was estimated in 28 out of 44 patients and of them 4 (14%) were positive.
The absence of Bence-Jones protein on the urine protein electrophoresis.
The serum protein electrophoresis (agarose gel) showed the presence of a monoclonal band in between beta and gamma regions and urine protein electrophoresis showed presence of Bence-Jones protein.
7) Thus, we hypothesized that Bence-Jones protein (BJP) quantitation by this technique is often misleading and that, instead, one may be able to use random urine protein/creatinine ratios to provide better information.
In about 75% of cases, free light chains are also over- produced to levels several thousands of times higher than normal and a corresponding increase in Bence-Jones protein is measurable on urine protein electrophoresis (UPEP).
Further investigations--including Bence-Jones protein urinalysis, skeletal survey, bone marrow aspiration, and trephine biopsy, as well as spinal MRI--revealed no evidence of myeloma.
Multiple myeloma: a plasma-cell cancer; currently incurable but treatable using various regimens; shows excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin (IgG, IgA, IgD, or IgE) or Bence-Jones protein (free monoclonal e or e light chains).