These cases are related to olmesartan products (Benicar
HCT, Azor and Tribenzor) and allegations that such products caused sprue-like enteropathy and other severe gastro-intestinal symptoms.
The drugs under the microscope are the Japanese pharma firm's blood-pressure treatments Benicar
HCT, Azor and Tribenzor.
The drug is the generic equivalent of Benicar
Tablets of Daiichi Sankyo Inc.
(branded for Olmesatan) used to treat hypertension; Lixiana in
is used in the treatment of hypertension and was responsible for about 27 percent of annual revenue for the company.
Expiry of the blockbuster patented drugs such as Gleevec, Namenda, Provigil, Crestor, Benicar
The treatment is made by Japanese firm Daiichi Sankyo and marketed as Benicar
outside the UK.
1, 2) Other drugs containing olmesartan include Benicar
HCT (olmesartan medoxomil/hydrochlorothiazide), Azor (olmesartan/ amlodipine), and Tribenzor (olmesartan/amlodipine/hydro-chlorothiazide).
Information about some of the studies reviewed by the FDA, including a large observational study of Medicare patients, will be included in the labels of olmesartan products, which include Benicar
HCT, AZO, Tribenzor, and generics.
The JNC 8 writers suggested doctors choose from an angiotensin-converting enzyme inhibitor (ACEI, such as Altace, Vasotec, Lotensin), angiotensin receptor blocker (ARB, such as Benicar
, Diovan), calcium channel blocker (CCB, such as Norvasc, Procardia) or thiazide diuretic (such as Esidrix or Zaroxolyn).
Daiichi Sankyo has started its business in Venezuela prior to the other Japanese pharmaceutical companies and has built its presence with innovative pharmaceuticals such as the hypertension medicine Benicar
Tribenzor combines amlodipine, marketed by Pfizer as Norvasc, olmesartan medoxomil, marketed by Daiichi Sankyo as Benicar
, and a third drug, hydrochlorothiazide.