In addition, beta-blockers
have been shown to slow the progression of heart failure, improve its severity and reduce the risk of arrhythmias.
In experiments with a different mouse model of pancreatic cancer, the CUMC team demonstrated that treating mice with chemotherapy and nonselective beta-blockers
, which are used to treat a variety of conditions, lived significantly longer than mice treated with chemotherapy alone.
APACHE-II scores and maximum HR<100/min were independent variables predicting ICU mortality in multivariate logistic regression analysis whereas usage of beta-blockers
A 2013 stratified subset meta-analysis used data from landmark randomized controlled trials (RCTs) that evaluated beta-blockers
vs placebo in patients with systolic heart failure to compare metoprolol succinate (MERIT-HF) vs placebo with bisoprolol (CIBIS-II), carvedilol (COPERNICUS), and nebivolol (SENIORS-SHF) vs placebo (table).
Generally, I think there is a consensus that beta-blockers
are a poor choice for uncomplicated hypertension," Dr.
work by blocking two hormones, adrenaline and noradrenaline, which are produced by the body and increase the heart rate and raise blood pressure.
This trial enrolled patients who, at baseline, were treatment naive to beta-blockers
, diuretics, statins and calcium channel blockers, the latter being used as metabolically neutral controls.
The study also looked at the relationship between brain lesions at autopsy with beta-blocker
treatment compared with other antihypertensive drugs, according to Dr.
may not be as effective for many patients as was previously thought.
At the end of surgery, an investigator asked the anaesthetist to nominate their reasons for either initiating or not initiating perioperative beta-blockade in patients who were not already on beta-blockers
as per the above definition using the following (one or more) alternatives:
are commonly used in the treatment of hypertension (high blood pressure) to help reduce the risk of stroke and cardiovascular disease.
increased antidepressant use in patients prescribed beta-blockers