lactam

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Related to Beta-lactam Ring: beta-lactamase

lac·tam

 (lăk′tăm)
n.
A cyclic amide, or any compound containing it, formed by the intramolecular condensation of an amino carboxylic acid.

lactam

(ˈlæktæm)
n
(Elements & Compounds) chem any of a group of inner amides, derived from amino acids, having the characteristic group -CONH-
[C20: from lact(one) + am(ide)]

lac•tam

(ˈlæk tæm)

n.
any of a group of cyclic amides characterized by the NHCO group.
[1880–85; lact (one) + am (ide)]
References in periodicals archive ?
The first wave began in mid-1940s with emergence of penicillin-resistance, because of plasmid encoded penicillinase that hydrolyses the beta-lactam ring of penicillin essential for its antimicrobial activity.
According to the studies, the percentage of methicillin resistant Staphylococcus aureus prevalence is due to different plans of hospitals and the less capability of coupling with penicillin binding proteins for antibiotics with beta-lactam ring and the excess of penicillinase production [22].
The AY-lactam antibiotics are inactivated by Beta-lactamases that hydrolyze the amide bond that exists in the beta-lactam ring, disrupting the ring structure and make the antibiotics nonfunctional against bacteria.

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