beta-lactam antibiotic


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beta-lactam antibiotic

n.
Any of a class of broad-spectrum antibiotics, such as the penicillins and the cephalosporins, that contain a beta-lactam ring.
References in periodicals archive ?
Regardless of the origins, which are likely to become obscured as clones move back and forth between hospital and community over time, emergence of MRSA within the community is a major threat with several important clinical implications: treatment failure with accompanying complications or death may result if an antistaphylococcal beta-lactam antibiotic is used and the infecting strain proves to be resistant; infections caused by methicillin-resistant strains may be more difficult to manage or more expensive to treat, perhaps because vancomycin is inherently less efficacious (29-33); and the increasing prevalence of MRSA will inevitably increase vancomycin use, adding further to the problem of antibiotic-resistant gram-positive bacteria.
MethylGene has designed and developed small molecules that inhibit the beta-lactamase enzymes, which are a major cause of resistance to these widely utilized antibiotics and these small molecules may be combined with any beta-lactam antibiotic.
This acquisition is expected to reduce Hospira's costs, support continuity of supply of key antibiotic products, pave the way for future API development, vertically integrate into certain critical beta-lactam antibiotic APIs (penems and penicillins) and improve its standard cost position in this therapeutic space.
In a rabbit model, biofilms on Foley catheter surfaces were highly resistant to high levels of amdinocillin, a beta-lactam antibiotic (30).
When used in combination with a beta-lactam antibiotic, these compounds can prevent resistance to the antibiotic and hence, enhance and prolong the activity of the antibiotic.
To overcome bacterial resistance to beta-lactams, current drugs combine a beta-lactam antibiotic and a beta-lactamase inhibitor.
A two-component drug containing an AlamX inhibitor and a beta-lactam antibiotic have the potential to treat a broad spectrum of microorganisms for which no effective therapies currently exist.
A chemically tweaked version of one of these molecules made 82 percent of tested MRSA strains vulnerable to a beta-lactam antibiotic.
The best evidence right now is that for simple cellulitis (no purulence, abscess, or exudate), treatment with a beta-lactam antibiotic is the best option.
The MaxSignal Beta-Lactam ELISA Test Kit was developed to ease these concerns and assure that food is free of beta-lactam antibiotic residues.
The combination of OP0595 with a beta-lactam antibiotic targets severe infections caused by Enterobacteriaceae, including multi-drug-resistant strains.

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