metformin

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Related to Biguanides: Sulfonylureas

met·for·min

 (mĕt-fôr′mĭn)
n.
An oral hypoglycemic drug, C4H11N5, usually used in its hydrochloride form, that decreases glucose production by the liver and increases peripheral glucose uptake, used to treat type 2 diabetes.

[Probably met(hyl) + form(ic acid) + -in.]

metformin

(mɛtˈfɔːmɪn)
n
(Pharmacology) a drug, C4H11N5, used to treat type 2 diabetes
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.metformin - an antidiabetic drug (trade name Glucophage) prescribed to treat type II diabetes
antidiabetic, antidiabetic drug - a drug used to treat diabetes mellitus
Translations

metformin

n metformina
References in periodicals archive ?
While its blood glucose-lowering effects in laboratory animals were known by the late 1920s, its importance as a potential treatment for diabetes was obscured by the high-profile nature of insulin, which was relatively inexpensive, more understood than the biguanides, easily obtained and known to be effective.
There are seven pharmacologic subclasses of oral antidiabetic agents: alpha-glucosidase inhibitors, biguanides, dipeptidyl peptidase-4 inhibitors, meglitinides, sulfonylureas, sodium-glucose cotransporter-2 inhibitors, and thiazolidinediones.
TYPES AND NAMES OF DIABETES MEDICATIONS* CLASS BRAND NAMES Biguanides Glucophage, Fortamet GLP-1 receptor agonists Trulicity, Tanzeum, Bydureon, Victoza DPP-IV inhibitors Januvia, Onglyza, Nesina SGLT-2 inhibitors Invokana, Farxiga, Jardiance Sulfonylureas Amaryl, Glucotrol, DiaBeta, Glynase Insulin Tresiba, Toujeo, Afrezza, Levemir, Lantus Combination drugs Janumet, Jentadueto, Kombiglyze, Tradjenta, Kazano, Oseni * This chart provides examples of some, but not all, medications used to treat diabetes.
The global diabetes drugs and devices market report estimates the market size (Revenue USD million - 2013 to 2020) for key market segments based on the drug type (insulin derivatives - short-acting, intermediate-acting, long-acting, premixed, and rapid-acting insulin; oral anti-diabetes drugs - alpha-glucosidase inhibitors, biguanides, DPP-4 inhibitors, meglitinides, SGLT-2 inhibitors, sulphonylureas, thiazolidinediones; and non-insulin injectable anti-diabetes drugs - GLP-1 analogs), device type (diabetes monitoring and diagnostic devices - analog glucose meter, continuous glucose monitoring devices, glucose test strips, lancets and lancing devices; insulin delivery devices - insulin injectors, pens, pumps, syringes, etc.
Biguanides inhibits pyruvate carboxylase and dehydrogenase and causes more lactate accumulation.
Metformin and other biguanides in oncology: Advancing the research agenda.
The longitudinal retrospective analysis of a large administrative claims database found a 10% incidence of fracture on sulfonylureas and 11% on thiazolidinediones, compared with 7% on biguanides (metformin), 8% on dipeptidyl peptidase-4 (DPP-4) inhibitors, 11% on meglitinide analogues, and 6% on incretin mimetic agents.
The discussion of biguanides, such as metformin (Glucophage[R]), on page 88, also contains incorrect information.
1920s Derivatives of goat's rue called biguanides are shown to lower blood sugar in rabbits.
This article will discuss the following classes of drugs: biguanides, thiazolidinedione agents (TZDs), sulfonylureas, meglinitides, glucagon-like peptide-1 (GLP-1) agonists, dipeptyl peptidase 4 (DDP-4) inhibitors, alpha-glucosidase inhibitors, amylin analogues, and insulin.
That led Shaw and his team to a class of drugs called biguanides, which lower cellular energy levels by attacking the power stations of the cell, called mitochondria.
The known toxic effect of biguanides is lactic acidosis in acute and chronic use.