PharmaMar presented new preclinical data on plitidepsin showing how it regulates the viability and function of bone cells
in combination with other anti-multiple myeloma drugs.
September 26, 2017 -- Adding or removing water from a stem cell can change the destiny of the cell to either pre-fat cells or pre bone cells
, researchers have discovered in a new study.
Scientists who studied the bones found in Poland and Germany believe the condition was triggered by the "bends", as rapid ascent in water destroys bone cells
We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells
from human pluripotent stem cells like induced pluripotent stem cells," Varghese said.
Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can encourage stem cells in the bone marrow to differentiate into bone cells
, and that specific biomolecules can inhibit or promote stem cell differentiation.
Using bone samples from people undergoing hip replacement surgery, researchers from the University of Southampton were able to show that the drug - a protein that activates a molecular pathway called the 'Wnt' pathway - causes stem cells found within bones to divide and to turn into more bone cells
Among specific topics are bone modeling and remodeling, skeletal hard tissue biomechanics, skeletal growth and development, hormonal effects on bone cells
, and pharmaceutical treatments of osteoporosis.
The study is novel in that the researchers directly delivered bone-producing instructions (using piece of DNA that encodes for a platelet-derived growth factor called PDGF-B) to existing bone cells
in vivo, allowing those cells to produce the proteins that led to more bone production.
Broken bones and joint replacements someday may heal faster, thanks to an unusual coating for medical implants under development, reports the journal Ceramics International, as researchers have found that bone cells
grow and reproduce faster on a textured surface than they do on a smooth one--and they grow best when they can cling to a microscopic shag carpet made of tiny metal oxide wires.
The findings confirmed previous work showing that tributyltin affects the regulation of body fat production and reprograms certain stem cells to become fat cells rather than bone cells
Libera has been awarded a patent titled “Surfaces Differentially Adhesive to Bacteria & Eukaryotic Cells” for a technology that repels bacteria and promotes the growth of bone cells
around an implant.
The ability to control whether certain stem cells ultimately become bone cells
holds great promise for regenerative medicine and potential therapies aimed at treating metabolic bone diseases.