To reach the findings, the researchers conducted a large study of more than 400,000 women to specifically look at family history as a breast cancer risk factor in two groups of women, ages 65-74 and 75 and older.
Kapil Kumar, Senior Consultant and Head of Breast, Thoracic and Soft Tissue Services, RGCI & RC highlighted low level of physical activity leading to obesity as a prime breast cancer risk factor among women.
Because this polymorphism is associated with lower production of the cytokine (15) and because IL-10 may play a protective and preventive role, at least in some cancers, it is conceivable that the IL-10 AA genotype might represent a breast cancer risk factor of low penetrance.
However, BMI functions as a breast cancer risk factor regardless of the levels of serum estrogen, which suggests that breast cancer risk is influenced by mechanisms apart from the estrogen stimulation of the breast.
It is reassuring that elevated breast density, a prevalent and strong breast cancer risk factor, was not associated with risk of breast cancer death or death from any cause in this large, prospective study," they said.