Methods: We retrospectively analyzed the association between thrombocytosis, leukocytosis and C difficile infections at the Atlanta Veterans Affairs Medical Center.
Results: Of 162 patients with C difficile infection, 36 (22%) had thrombocytosis, and 97 (60%) had leukocytosis.
Conclusions: The presence of thrombocytosis may be helpful to improve the pretest probability for C difficile infections.
2) Standard diagnostic tests, which detect C difficile toxins in stool by enzyme immunoassays, are both sensitive and specific.
In another experiment, hamsters were challenged by C difficile
delivered orally, followed by a dose of clindamycin to create an even more severe test of the effects of Ramoplanin, vancomycin and metronidazole.