Incomplete CD4 T cell
recovery in HIV-1 infection after 12 months of highly active antiretroviral therapy is associated with ongoing increased CD4 T cell
activation and turnover.
CD4 T cell
help is limiting and selective during the primary B cell response to influenza virus infection.
Comparison of mean CD4+ T cell counts between Ethiopian and Dutch populations showed considerably lower CD4 T cell
counts in Ethiopian population (mean=775 cells/[micro]l) as compared to Dutch populations (mean= 993 cells/[micro]l) (58).
Characteristics, determinants, and clinical relevance of CD4 T cell
recovery to <500 cellsl/[micro]L in HIV type 1-infected individuals receiving potent antiretroviral therapy.
In some cases, treatment is interrupted according to a scheduled time frame, while other studies have used CD4 T cell
counts or viral load as indicators of when to stop or re-initiate therapy.
We also assessed the reproducibility of the Capcellia assay by comparison of CD4 T cell
counts determined by two trained technicians (Fig.
The identification of the major HIV CD4 T cell
reservoir will be instrumental in developing therapeutic strategies to selectively target HIV infected Tfh cells," says Prof.
The CD4 T cell
count in peripheral blood is an important prognostic marker in the context of HIV infection.
Though viral load control in HIV-infected patients is an attainable goal with the current potent HAART regimen, the magnitude of CD4 restoration among patients remains variable and the length of time patients spend with low CD4 T cell
counts is clearly associated with a higher morbidity," said Yves Levy MD, PhD, Scientific Director of the French National Agency for Research on AIDS and Viral Hepatitis (ANRS) Vaccine Program, Service d'Immunologie Clinique, Hypital Henri Mondor, Creteil, France and Inserm, Principle Investigator and lead author of the publication.
One of the first indications of this premise was the observation that viral loads increase and CD4 T cell
counts fall in patients stopping therapy.
Multiple copies of this so-called CCR5 receptor sit on the surface of each CD4 T cell
While the incidence of ARL in HIV infection has decreased overall since the advent of HAART, there has been no change within any patient grouping defined by CD4 T cell