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CD4 cell |
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Costs among the sickest patients (those with the lowest CD4 cell counts) come to nearly triple those among individuals whose disease is least advanced. Patients must be three-class experienced with at least two PI-based regimens, and have a CD4 cell count of equal or less than 200 cells/mm3. The problem with CD4 cell changes as a surrogate marker was that CD4 cell count was a direct marker of a person's immune status, but only an indirect marker of anti-HIV drug activity (it rose when HIV levels fell). |
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