cytotoxic T cell

(redirected from CD8 T-cells)
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Related to CD8 T-cells: Killer T cells

cytotoxic T cell

killer T cell


n.
a killer cell that destroys target cells only when specifically activated by helper T cells.
Compare natural killer cell.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cytotoxic T cell - T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it
T cell, T lymphocyte - a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
References in periodicals archive ?
Animal studies showed that CD4 and CD8 T-cells of PD-1 expression increased by 48 h after cecal ligation and puncture (CLP).
In patients with AIDS, the human immunodeficiency virus (HIV) keeps CD4 and CD8 T-cells in constant activation thus leading to a chronic inflammatory state.
It has been shown that CMV chronic infection in old individuals is associated with accumulations of late-differentiated CD8 T-cells, characteristic of CD8 T-cell immunosenescence, and with the development of an 'Immune Risk Phenotype' (IRP), predictive of early mortality in the elderly indicating that this virus is a major driving force of T-cell immunosenescence.
Human leukocyte antigen (HLA) class I molecules present endogenously acquired antigenic peptides on the surface of infected cells to adaptive CD8 T-cells, so leading to targeted cell killing by these T cells.
Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization.
First, they exposed the CD8 T-cells from HIV-infected persons to TAT2 to see if the chemical not only slowed the shortening of the telomeres but also improved the cells'' production of soluble factors called chemokines and cytokines, which had been previously shown to inhibit HIV replication.
Recent studies suggest that CD8 T-cells have distinctive role in immunity against Mycobacterium tuberculosis, for example they preferentially use granule exocytosis pathway and recognize heavily infected cells [5], ingest macrophages that have engulfed mycobacteria [7], secrete cytokines and lyse infected cells [6].