cytotoxic T cell

(redirected from CD8 T-cells)
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Related to CD8 T-cells: Killer T cells

cytotoxic T cell

killer T cell


n.
a killer cell that destroys target cells only when specifically activated by helper T cells.
Compare natural killer cell.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cytotoxic T cell - T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it
T cell, T lymphocyte - a small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
References in periodicals archive ?
They used messenger RNA and electroporation to deliver the ZFNs and a non-integrating vector, an adeno-associated virus (AAV) serotype 6, to provide a therapeutic DNA sequence, a so-called "donor template", to HSPCs and CD4 and CD8 T-cells.
Human leukocyte antigen (HLA) class I molecules present endogenously acquired antigenic peptides on the surface of infected cells to adaptive CD8 T-cells, so leading to targeted cell killing by these T cells.
It has been shown that CMV chronic infection in old individuals is associated with accumulations of late-differentiated CD8 T-cells, characteristic of CD8 T-cell immunosenescence, and with the development of an 'Immune Risk Phenotype' (IRP), predictive of early mortality in the elderly indicating that this virus is a major driving force of T-cell immunosenescence.
They treated the CD8 T-cells with TAT2 and combined them with the CD4 T-cells in the dish-and found that the treated CD8 cells inhibited production of HIV by the CD4 cells.
Data from INSPIRE 2 HIV Study Show That CYT107 Administration Can Significantly Expand CD4 and CD8 T-cells with Lower Expression of PD-1 While Increasing the Expression of Gut Homing Molecules That May Result in the Restoration of the CD4 T-cell Population of the Gut Mucosa
An additional five subjects will be accrued into this cohort to further evaluate the inclusion of ZFN-modified CD8 T-cells in the cell product.
Clinical trials including more than 180 patients in Europe, North America, South Africa and Taiwan have demonstrated the potential of IL-7 to expand and protect CD4 and CD8 T-cells.
ICAAC Presentation of Updated Clinical Data from Sangamo's SB-728-T Program In a presentation at this year's ICAAC meeting, Sangamo scientists reported on the progress of two of three subjects in Cohort 3*, who had received an SB-728 product that included CCR5 modified CD8 T-cells.
In mice, the adeno-associated virus, or AAV vaccines, directly interfered with immune cells called CD8 T-cells .
Results showed IAB22M2C could detect human CD8 T-cells in the spleens of mice one week post engraftment.
2% increase in the ratio of beneficial CD4 T-cells to CD8 T-cells.
HLA-B27 restricted CD8 T-cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis.