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CFTR |
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In the new study, scientists used parainfluenza virus, one of the viruses that causes common colds, and found that delivery of a corrected version of the CFTR gene to 25 percent of cells grown in a tissue culture model that resembles the lining of the human airways was sufficient to restore normal function back to the tissue. Topics include macromolecular modeling with Rosetta, protein interaction networks, structural biology of the tumor suppressor p53, maturation of iron-sulfur proteins in eukaryotes, and cystic fibrosis therapies based on CFTR function. [FIGURE 1 OMITTED] The CFTR gene The pathophysiology of CF results from mutations in the cystic-fibrosis transmembrane regulator (CFTR) gene. |
CFTR |
CFTFK CFTG CFTGE CFTGEC CFTH CFTHA CFTI CFTIC CFTK CFTL CFTLA CFTLC CFTLIB CFTM CFTN CFTNM CFTNU CFTO CFTO-TV mast CFTOC Cftp CFTPA CFTPO CFTPT CFTR CFTR Associated Protein of 70 kDaCFTRA CFTRC CFTRE CFTRI CFTRR CFTS CFTT CFTTC CFTU CFTUI CFTUK CFTUU CFTVC CFTW CFTZ CFU CFU CFU-C CFU-dg CFU-E CFU-F CFU-G CFU-GEMM CFU-GM | ||||||||
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