Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
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Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
Carcinogenesis and cyclooxygenase: The potential role of COX-2 inhibition in upper aerodigestive tract cancer.
NSAIDs act mainly through the inhibition of COX activity in the biochemical cascade that leads to prostaglandin synthesis, and there are selective NSAIDs for COX-2 inhibition (KHWANJAI et al.
2010) and concluded that COX-2 inhibition resulted in decrease production of anti-bodies against the virus.
Because hypoxia-induced cell invasion has been shown to involve COX-2 inhibition, we examined the effects of methyl syringate on hypoxia-induced COX-2 expression and found that it efficiently blocks this outcome.
Furthermore, NS398 pretreatment significantly inhibited proinflammatory cytokine expressions (IL6 and TNF[alpha]), reduced the formation of ROS, and enhanced the activation of Akt/iNOS/NO signaling pathway, which could represent the mechanisms whereby COX-2 inhibition attenuated H/R-induced cell apoptosis in cardiomyocytes.
The process of the COX-2 inhibition of apoptosis is possibly connected with the removal of the substrate arachidonic acid by COX-2 catalytic activity or the generation of prostaglandin products.
Selective COX-2 inhibition improves endothelial function in coronary artery disease.
While it is agreed that conventional COX-2 inhibition relieves pain symptoms, some researchers admit that it has little or no effect on any underlying degenerative process.
It is hypothesized that prolonged high levels of COX-2 inhibition in the plasma can lead to an increased risk of vascular events.
Prospective evaluation of aspirin and COX-2 inhibition in the PIK3CA-mutant population is definitely needed.
Meloxicam contained in Melonex (c) was used for having long term benefits in suppression of inflammatory responses without gastrointestinal complications for its selective COX-2 inhibition.
Whether Aceclofenac may have less propensity to cause cardiovascular adverse events due to its preferential COX-2 inhibition (38,39), will need further evaluation.