Cox-2 inhibitor

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COX-2 inhibitor

Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.
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Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract
References in periodicals archive ?
In order to examine whether Sirt1 activation is involved in COX-2 inhibition by KRG-WE, we examined the protein levels by using a Sirt1 specific inhibitor, sirtinol.
11] Moreover, it was recently demonstrated that acute BUO leads to marked upregulation of COX-2 in inner medulla; selective COX-2 inhibition prevents dysregulation of AQP2 in response to BUO, indicating that COX-2 may be an important factor contributing to the impaired renal water and sodium handling in response to BUO.
While it is agreed that conventional COX-2 inhibition relieves pain symptoms, some researchers admit that it has little or no effect on any underlying degenerative process.
Prospective evaluation of aspirin and COX-2 inhibition in the PIK3CA-mutant population is definitely needed.
The scientists are pursuing other potential applications of activating endocannabinoids by substrate-selective COX-2 inhibition, including relieving pain, treating movement disorders, and possibly preventing colon cancer.
COX-2 inhibition results in increasing the activity of the lipoxygenase pathway and significant modulation of cytokine and NFkB-related gene expression.
Five years ago, before COX-2 inhibitor drugs imploded in a mass of serious side effects, many herbal pain reliever products were claiming COX-2 inhibition.
Selective COX-2 inhibition reduces vascular prostacyclin synthesis without disrupting COX-1-derived thromboxane synthesis in platelets.
However, COX-2 inhibition was reversed by the presence of high levels of arachidonic acid suggesting that in inflammatory states, COX-2 inhibition is unlikely to be relevant.
The role of COX-2 inhibition in breast cancer treatment and prevention.