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COX-2 inhibitor

   Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson 0.04 sec.
COX-2 inhibitor  (kkst)
n.
Any of a class of nonsteroidal anti-inflammatory drugs thought to have fewer side effects than traditional NSAIDs.

[From c(yclo)ox(ygenase)-2, enzyme involved in the production of prostaglandins.]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract

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Two nearly identical trials began in 1999 and 2001 but were stopped in 2004 when more than the expected number of participants developed heart problems while taking the drug, a COX-2 inhibitor.
From our perspective, it's that the FDA said Cox-2 inhibitors are associated with an increased risk of cardiovascular events.
Don't write off the entire COX-2 inhibitor class of drugs, says Dr.
 
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