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COX-2 inhibitor

   Also found in: Medical, Encyclopedia, Wikipedia, Hutchinson 0.04 sec.
COX-2 inhibitor  (kkst)
n.
Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects.

[From c(yclo)ox(ygenase)-2, enzyme involved in the production of prostaglandins.]
ThesaurusLegend:  Synonyms Related Words Antonyms
Noun1.Cox-2 inhibitor - an anti-inflammatory drug that fights pain and blocks Cox-2 activity without impeding the activity of Cox-1; increases the risk of heart attacks; "Cox-2 inhibitors reduce the symptoms of arthritis without endangering the stomach and kidneys"
anti-inflammatory, anti-inflammatory drug - a medicine intended to reduce inflammation
Celebrex, celecoxib - a Cox-2 inhibitor (trade name Celebrex) that relieves pain and inflammation without harming the digestive tract
rofecoxib, Vioxx - a Cox-2 inhibitor (trade name Vioxx) that relieves pain and inflammation without harming the digestive tract; voluntarily withdrawn from the market in 2004
Bextra, valdecoxib - a Cox-2 inhibitor (trade name Bextra) that relieves pain and inflammation without harming the digestive tract


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? Mentioned in ? References in periodicals archive
 
Two nearly identical trials began in 1999 and 2001 but were stopped in 2004 when more than the expected number of participants developed heart problems while taking the drug, a COX-2 inhibitor.
From our perspective, it's that the FDA said Cox-2 inhibitors are associated with an increased risk of cardiovascular events.
Don't write off the entire COX-2 inhibitor class of drugs, says Dr.
 
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