Calpain-1 - definition of Calpain-1 by The Free Dictionary
calpain (redirected from Calpain-1)
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A proteolytic enzyme regulated by the concentration of calcium ions.
any of various enzymes in mammals and other organisms that are involved in the proteolysis of endogenous proteins and are regulated by the concentration of calcium ions
[C20: from cal(modulin) + (pa)pain]
References in periodicals archive
Calpain, also known as calcium-dependent protease system, is an effective molecule reacting to an intracellular calcium signal, calpain-1
, which has been shown to selectively cleave some apoptotic proteins (e.
Targeted gene inactivation of calpain-1
suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
81] very elegantly showed that [alpha] subunit is a target for calpain-1
in diabetic hearts, leading to its proteolytic degradation, reduction in ATP synthase activity, increase in mitochondrial superoxide formation, and diabetic cardiomyopathy in mice.