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A proteolytic enzyme regulated by the concentration of calcium ions.

[Probably cal(cium) + p(rote)a(se) + -in.]


any of various enzymes in mammals and other organisms that are involved in the proteolysis of endogenous proteins and are regulated by the concentration of calcium ions
[C20: from cal(modulin) + (pa)pain]
References in periodicals archive ?
Calpain, also known as calcium-dependent protease system, is an effective molecule reacting to an intracellular calcium signal, calpain-1, which has been shown to selectively cleave some apoptotic proteins (e.
Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
81] very elegantly showed that [alpha] subunit is a target for calpain-1 in diabetic hearts, leading to its proteolytic degradation, reduction in ATP synthase activity, increase in mitochondrial superoxide formation, and diabetic cardiomyopathy in mice.